Substituted tetrahydropyrazolo-pyrido-azepine compounds

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C514S183000

Reexamination Certificate

active

08049005

ABSTRACT:
The present invention relates to substituted tetrahydropyrazolo-pyrido-azepine compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted tetrahydropyrazolo-pyrido-azepine compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds and pharmaceutical compositions to subjects in need thereof.

REFERENCES:
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patent: WO-2009023269 (2009-02-01), None
patent: WO-2009042711 (2009-04-01), None
Han, J. ‘Advanaces in the Characterization of Pharmaceutical Hydrates’ Trends in Bio/Pharmaceutical Industry, vol. 3, p. 25-29, 2006.
Stella et al ‘Prodrugs: Challenges and Rewards, Part 1’ Biotechnology: Pharmaceutical Aspects, p. 24, 2007.
Vippagunta et al ‘Crystalline Solids’ Advanced Drug Delivery Reviews, vol. 48, p. 3-26, 2001.
Kohfeld et al. “1-Aryl-4,6-dihydropyrazolo[4,3-d][1]benzazepin-5(1H)-ones: A new class of antiproliferative agents with selectivity for human leukemia and breast cancer cell lines” European Journal of Medicinal Chemistry, Editions Scientifique Elsevier, Paris, FR vol. 42:11-12, pp. 1317-1324 (2007).
International Search Report & Written Opinion for PCT/US2010/029414.

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