GlyT1 receptor antagonists

Details GlyT1 receptor antagonists GlyT1 receptor antagonists

2009-08-14

2011-11-22

Shameem, Golam M (Department: 1622)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C548S566000, C548S567000, C544S106000, C514S231200, C514S408000

Reexamination Certificate

active

08063098

ABSTRACT:
The present invention relates to a compound of formula IwhereinR1, R2, X, Ar1and Ar2are as defined herein and to pharmaceutically acceptable acid addition salts, to a racemic mixtures, or to their corresponding enantiomers and/or optical isomers thereof. Compounds of the invention are good inhibitors of the glycine transporter 1 (GlyT-1), and have a good selectivity to glycine transporter 2 (GlyT-2) inhibitors.

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