Pharmaceutical compositions comprising docetaxel and methods...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Reexamination Certificate

active

08044093

ABSTRACT:
A pharmaceutical composition of docetaxel comprising an effective amount of docetaxel, a polysorbate (TWEEN® compound) and a co-solvent, wherein the co-solvent is at least one member selected from the group consisting of glycerol and polyethylene glycol. The composition is an injectable solution or a freeze-dried powder for injection. The solubility of decetaxel is improved by adding a polysorbate and a co-solvent. Methods of preparation of the pharmaceutical composition are also disclosed.

REFERENCES:
patent: 5698582 (1997-12-01), Bastart et al.
patent: 6251428 (2001-06-01), Yoo
patent: 6388112 (2002-05-01), Anevski
patent: 6828346 (2004-12-01), Joshi-Hangal et al.
patent: 2003/0077297 (2003-04-01), Chen et al.
patent: 2003/0207936 (2003-11-01), Chen
patent: WO 97/23208 (1997-07-01), None
patent: WO 2006/133510 (2006-12-01), None
Chen et al. Pharmaceutical Research, Aug. 2003, vol. 20, No. 8, pp. 1302-1308.

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