Mutant phosphoribosylpyrophosphate synthetase and method for...

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing alpha or beta amino acid or substituted amino acid...

Reexamination Certificate

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C435S106000, C435S193000, C435S194000, C435S252300, C435S252330, C435S252800, C435S471000, C435S488000, C435S069100, C435S320100

Reexamination Certificate

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08071339

ABSTRACT:
The present invention relates to a mutant bacterial PRPP synthetase which is resistant to feedback by purine nucleotides, and a method for producing L-histidine using the bacterium of the Enterobacteriaceae family wherein the L-amino acid productivity of said bacterium is enhanced by use of the PRPP synthetase which is resistant to feedback by purine nucleotides, coded by the mutant prsA gene.

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