Prodrugs of CGRP receptor antagonists

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C540S487000

Reexamination Certificate

active

08080544

ABSTRACT:
Disclosed are prodrug compounds of formula (I) (wherein variables R1and R2are as described herein) which are analogues of an antagonist of CGRP receptors and which are useful in the treatment or prevention of diseases in which CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

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Co-pending U.S. Appl. No. 12/086,670, filed Jun. 13, 2008.
Co-pending U.S. Appl. No. 12/310,808, filed Mar. 6, 2009.
Co-pending U.S. Appl. No. 12/831,802, filed Jul. 7, 2010.
Supplementary European Search Report and Search Opinion for counterpart European patent application No. EP 09 70 8648.

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