Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2011-04-28
2011-12-06
Pak, Michael (Department: 1646)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
Reexamination Certificate
active
08071744
ABSTRACT:
The present invention provides methods for detecting changes in tryptophan concentrations in a cell and methods for identifying agents that modulate cellular tryptophan concentrations. In particular, the present invention provides methods for detecting cellular exchange between tryptophan and kynurenine, and methods for identifying agents that modulate this exchange. The present invention also provides methods for treating a disease associated with immunosuppression in a subject in need thereof. In particular, the present invention is directed toward a method of treating a disease associated with immunosuppression comprising contacting the disease with an agent that modulates cellular Trp/kynurenine exchange. Furthermore, the present invention provides methods for identifying an agent that modulates an immunosuppression.
REFERENCES:
patent: 2004/0157917 (2004-08-01), Gobaille
patent: 2005/0064475 (2005-03-01), Endou
patent: 2010/0138944 (2010-06-01), Frommer
Frommer Wolf
Kaper Thijs
Platten Michael
Steinman Lawrence
Carnegie Institution of Washington
Morgan, Lewis & Bockisu LLP
Pak Michael
The Board of Trustees of the Leland Stanford Junior University
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