Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2007-12-10
2011-12-13
Monshipouri, Maryam (Department: 1656)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
Reexamination Certificate
active
08076298
ABSTRACT:
The present invention provides a method for preventing and/or treating subjects with acute renal failure caused by a variety of conditions. The method comprises administering to the subject soluble thrombomodulin which does not activate Protein C. In conjunction with standard of care, soluble thrombomodulin that does not activate Protein C will prevent or reduce acute kidney injury and subsequent morbidity and mortality.
REFERENCES:
patent: 0 412 841 (1991-02-01), None
patent: WO 2007/047430 (2007-04-01), None
Faioni, Elena M. et al., “Mutations in the thrombomodulin gene are rare in patients with severe thrombophilia”,British Journal of Haematology, Aug. 2, 2002, pp. 595-599, vol. 118.
Database Uniprot, ebi; Nov. 28, 2006,“TRBM—HUMAN—entry version 105” XP002503077 retrieved from EBI accession No., UNIPROT:P07204 Database accession No. P07204.
Parkinson, J.F., et al., “Stable Expression 1-6, 9, 12 of a Secretable Deletion Mutant of Recombinant Human Thrombomodulin in Mammalian Cells”, Journal of Biological Chemistry, vol. 265, No. 21, 1990, pp. 12602-12610.
Grinnell Brian William
Jones Bryan Edward
Molitoris Bruce A.
Eli Lilly and Company
Indiana University Research and Technology Corporation
Martinez Alejandro
Monshipouri Maryam
LandOfFree
Treating acute renal failure with soluble thrombomodulin... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Treating acute renal failure with soluble thrombomodulin..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Treating acute renal failure with soluble thrombomodulin... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4265126