Guanidinium derivatives for improved cellular transport

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Reexamination Certificate

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C514S037000, C514S039000, C514S041000, C514S043000, C536S013200, C536S013600, C536S013700, C536S022100

Reexamination Certificate

active

08071535

ABSTRACT:
Reagents and methods useful for the synthesis of conjugates comprising guanidinylated cyclic acetals are provided. Also provided are methods for increasing the cellular uptake of various therapeutic compounds and treatment modalities using these conjugates.

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