Therapeutic compositions containing at least one...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C514S263100

Reexamination Certificate

active

08034808

ABSTRACT:
The invention concerns the use of a therapeutic composition comprising at least one pyrrolobenzodiazepine derivative combined with fludarabine for treating cancer and more particularly hematological diseases.

REFERENCES:
patent: 7511032 (2009-03-01), Liu et al.
patent: WO 00/12508 (2000-03-01), None
patent: WO 2005/105113 (2005-11-01), None
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Robert A. Kratzke et al., “Evaluation of In Vitro Chemosensitivity Using Human Lung Cancer Cell Lines”, J. of Cellular Biochem. Suppl., vol. 24, pp. 160-164, 1996.
Dr. Pepper et al. “Fludarabine-mediated suppression of the excision repair enzyme ERCC1 contributes to the cytotoxic synergy with the DNA minor groove crosslinking agent SJG-136 (NSC 694501) in chronic lymphocytic leukaemia cells” British Journal of Cancer, vol. 97, pp. 253-259, 2007.

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