Classifying – separating – and assorting solids – Precedent preparation of items or materials to facilitate... – Selective differentiation
Reexamination Certificate
2009-07-31
2011-12-27
Rodriguez, Joseph C (Department: 3653)
Classifying, separating, and assorting solids
Precedent preparation of items or materials to facilitate...
Selective differentiation
C209S158000, C209S214000, C209S232000, C210S222000
Reexamination Certificate
active
08083069
ABSTRACT:
The present application discloses a process for the high throughput separation of at least one distinct biological material from a sample using magnetic tags and a magnetic separation set up capable of processing at least about 106units/second. A magnetic field gradient is used to deflect target material bearing a magnet tag from one laminar flow stream to another so that the magnetically tagged target material exits a separation chamber via a different outlet than the rest of the sample. The process is applicable to isolating several distinct biological materials by directing each via magnetic deflection to its own unique outlet. The application also discloses a system for performing the process and a kit that includes the system and the magnetic tags.
REFERENCES:
patent: 3463319 (1969-08-01), Moragne
patent: 3970518 (1976-07-01), Giaever
patent: 4375407 (1983-03-01), Kronick
patent: 4769130 (1988-09-01), Christensen
patent: 4816143 (1989-03-01), Vollmar
patent: 4913883 (1990-04-01), Imai et al.
patent: 4941969 (1990-07-01), Schonert et al.
patent: 5411863 (1995-05-01), Miltenyi
patent: 5458785 (1995-10-01), Howe et al.
patent: 5514340 (1996-05-01), Lansdorp et al.
patent: 5543289 (1996-08-01), Miltenyi
patent: 5693539 (1997-12-01), Miltenyi et al.
patent: 5976369 (1999-11-01), Howe et al.
patent: 5981297 (1999-11-01), Baselt
patent: 6013188 (2000-01-01), Terstappen et al.
patent: 6020210 (2000-02-01), Miltenyi
patent: 6120735 (2000-09-01), Zborowski et al.
patent: 6126835 (2000-10-01), Barbera-Guillem et al.
patent: 6241894 (2001-06-01), Briggs et al.
patent: 6297061 (2001-10-01), Wu et al.
patent: 6337215 (2002-01-01), Wilson
patent: 6413420 (2002-07-01), Foy et al.
patent: 6417011 (2002-07-01), Miltenyi
patent: 6432630 (2002-08-01), Blankenstein
patent: 6437563 (2002-08-01), Simmonds et al.
patent: 6597176 (2003-07-01), Simmonds et al.
patent: 6657713 (2003-12-01), Hansen
patent: 6713299 (2004-03-01), Sengoku
patent: 6849186 (2005-02-01), Johnson et al.
patent: 6929750 (2005-08-01), Laurell et al.
patent: 7179391 (2007-02-01), Leach et al.
patent: 7226537 (2007-06-01), Broyer et al.
patent: 7232691 (2007-06-01), Kraus et al.
patent: 7332352 (2008-02-01), Reeve
patent: 7360657 (2008-04-01), Oder et al.
patent: 2002/0000398 (2002-01-01), Skold
patent: 2002/0074266 (2002-06-01), Franzreb et al.
patent: 2002/0137226 (2002-09-01), Tanaami
patent: 2002/0146848 (2002-10-01), Reeve
patent: 2002/0162798 (2002-11-01), Johnson et al.
patent: 2002/0166800 (2002-11-01), Prentiss et al.
patent: 2003/0052426 (2003-03-01), Andersson et al.
patent: 2003/0186465 (2003-10-01), Kraus et al.
patent: 2004/0065593 (2004-04-01), Duo
patent: 2004/0108253 (2004-06-01), Broyer et al.
patent: 2004/0219066 (2004-11-01), Kraus et al.
patent: 2004/0235196 (2004-11-01), Colin
patent: 2005/0013741 (2005-01-01), a'Brassard
patent: 2005/0035030 (2005-02-01), Oder et al.
patent: 2005/0110176 (2005-05-01), Andersson et al.
patent: 2005/0274650 (2005-12-01), Frazier et al.
patent: 2008/0124779 (2008-05-01), Oh et al.
patent: 2008/0152939 (2008-06-01), Alterman et al.
patent: 2008/0283792 (2008-11-01), Axen et al.
patent: 2009/0044619 (2009-02-01), Fiering et al.
patent: 2009/0047297 (2009-02-01), Kim et al.
patent: 2009/0078614 (2009-03-01), Varghese et al.
patent: 2009/0092837 (2009-04-01), Axen et al.
patent: 2009/0139908 (2009-06-01), Zhou et al.
patent: 2009/0197329 (2009-08-01), Lee et al.
patent: 2009/0220932 (2009-09-01), Ingber et al.
patent: 3827252 (1990-02-01), None
patent: 9112079 (1991-08-01), None
patent: WO9111716 (1991-08-01), None
patent: 2008127292 (2008-10-01), None
Adams, J. D., et al., “Multitarget magnetic activated cell sorter”, Proc. National Academy of Sciences, 2008, 105:18165-18170.
Busch, et al., “Enrichment of Fetal Cells From Maternal Blood by High Gradient Magnetic Cell Sorting (Double Macs) For PCR-Based Genetic Analysis”, Prenatal Diagn, 1994; 14:1129-1140.
de Wynter, E. W., et al., “Comparison of Purity and Enrichment of CD34' Cells from Bone Marrow, Umbilical Cord and Peripheral Blood (Primed for Apheresis) Using Five Separation Systems”, Stem Cells, 1995, 13:524-532.
Fuh, C. B., et al., “Development of magnetic split-flow thin fractionation for continuous particle separation”, Anal. Chim Acta, 2003, 497:115-122.
Giddings, J.C., “Field-Flow Fractionation: Analysis of Macromolecular, Colloidal, and Particulate Materials”, Science, vol. 260, 1993, pp. 1456-1465.
Gupta, A.K., et al., “Receptor-Mediated Targeting of Magnetic Nanoparticles Using Insulin as a Surface Ligand to Prevent Endocytosis”, IEEE Trans. on Nanobioscience, 2003, 2:255-261.
Gupta, P.K. et al., “Magnetically Controlled Targeted Micro-Carrier Systems”, Life Sci., 1989, 44:175-186.
Handgretinger, et al., “Biology and Plasticity of CD 133 Hematopoietic Stem Cells”, Annals of New York Academy of Sc., 2003, 996:141-151.
Hansel, T.T., et al., “An improved immunomagnetic procedure for the isolation of highly purified human blood eosinophils”, J Immunol Methods, 1991, 145:105-110.
Happel, J. et al., “Low Reynolds Number Hydrodynamics”, Prentice Hall Inc. Publisher, Englewood Cliffs, NJ, US, pp. 273-285 (1965).
Hartig, R., et al., “Preparative continuous separation of biological particles by means of free-flow magnetophoresis in a free-flow electrophoresis chamber”, Electrophoresis, 1992, 13:674-676.
Kato, K. et al., “Isolation and Characterization of CD34 + Hematopoietic Stem Cells From Human Peripheral Blood by High-Gradient Magnetic Cell Sorting”, Cytometry, 1993, 14:384-392.
Krishnamurthy, H., et al., “Quantification of Apoptotic Testicular Germ Cells in Normal and Methoxyacetic Acid-Treated Mice as Determined by Flow Cytometry”, J Androl, 1998, 19:710-717.
Leary, J.F., “Ultra High-Speed Sorting”, Cytometry A, 2005, 67A:76-85.
Pamme, N. et al., “Continous sorting of magnetic cells via on-chip free-flow magnetophoresis”, Lab Chip, 2006, 6:974-980.
Powles, R., et al., “Allogeneic blood and bone-marrow stem-cell transplantation in haematological malignant diseases: a randomised trial”, Lancet, 2000, 355:1231-1237.
Schmitz, B., et al., “Magnetic activated cell sorting (MACS)—a new imrnunomagnetic method for megakaryocytic cell isolation: Comparison of different separation techniques”, Eur J Haematol 1994; 52:267-275.
Schmitz, J., et al., “Optimizing follicular dendritic cell isolation by discontinuous gradient centrifugation and use of the magnetic cell sorter (MACS)”, Journal of Immunological Methods, 159 (1993) 189-196.
Seidl, J., et al., “Evaluation of Membrane Physiology Following Fluorescence Activated or Magnetic Cell Separation”, Cytometry, 1999, 36:102-111.
Semple, J.W., et al., “Rapid Separation of CD4 + and CD19 + Lymphocyte Populations From Human Peripheral Blood by a Magnetic Activated Cell Sorter (MACS)”, Cytometry 1993, 14:955-960.
Takayasu, M., et al., “Continuous Magnetic Separation of Blood Components from Whole Blood”, IEEE Trans. Appl. Superconductivity, 2000, 10:927-930.
Weissman, I. L., “Translating Stem and Progenitor Cell Biology to the Clinic: Barriers and Opportunities”, Science, 2000, 287:1442-1446.
Zborowski, M., et al.,“Continuous cell separation using novel magnetic quadrupole flow sorter”, J. Magn. Magn. Mater., 1999, 194:224-230.
Zborowski, M, et al., “Red Blood Cell Magnetophoresis”, Biophysical J., 2003, 84:2638-2645.
Zborowski, M., et al., “Magnetic Cell Sorting Immunochemical Protocols”, 2005, 295:291-300.
Bray James William
Chandrasekaran Shankar
Dulgar-Tulloch Aaron Joseph
Murthy Sunil Srinivasa
Tiwari Arvind Kumar
General Electric Company
Haeckl Jenifer E.
Rodriguez Joseph C
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