Neurotensin receptor agonists and opioid receptor agonists

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Reexamination Certificate

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C514S282000

Reexamination Certificate

active

08058230

ABSTRACT:
This document provides methods and materials for treating pain. For example, this document provides methods that involve administering a neurotensin receptor (NTR) agonist and an opioid receptor agonist to a mammal (e.g., a human). Compositions containing an NTR agonist in combination with an opioid receptor agonist also are provided.

REFERENCES:
patent: 4254107 (1981-03-01), Veber
patent: 4299838 (1981-11-01), Durlach
patent: 4331646 (1982-05-01), Delaage
patent: 4518587 (1985-05-01), Laruelle
patent: 5393740 (1995-02-01), Amagaya
patent: 5578651 (1996-11-01), Lamberts et al.
patent: 5631265 (1997-05-01), Audia
patent: 6046180 (2000-04-01), Jackson
patent: 6214790 (2001-04-01), Richelson
patent: 6765099 (2004-07-01), Richelson
patent: 6921805 (2005-07-01), Richelson
patent: 7098307 (2006-08-01), Richelson
patent: 7671025 (2010-03-01), Barbut et al.
patent: 2002/0187958 (2002-12-01), Horrobin
patent: 2007/0015718 (2007-01-01), Mitchell
patent: 2008/0167388 (2008-07-01), Demopulos
patent: 0 333 071 (1989-09-01), None
patent: WO 96/03400 (1996-02-01), None
patent: WO 96/39162 (1996-12-01), None
patent: WO 97/48400 (1997-12-01), None
Al-Rodhan NR et al., “Structure-antinociceptive activity of neurotensin and some novel analogues in the periaqueductal gray region of the brainstem,” Brain Res. 557: 227-235 (1991).
Bissette G et al., “Hypothermia and intolerance to cold induced by intracisternal administration of the hypothalamic peptide neurotensin,” Nature 262:607-609 (Aug. 12, 1976).
Carraway R and SE Leeman, “The isolation of a new hypotensive peptide, neurotensin, from bovine hypothalami,” J. Biol. Chem. 248: 6854-6861 (Oct. 10, 1973).
Clineschmidt BV and JC McGuffin, “Neurotensin administered intracisternally inhibits responsiveness of mice to noxious stimuli,” Eur. J. Pharmacol. 46: 395-396 (1977).
Cusack B et al., “Pharamacological and biochemical profiles of unique neurotensin 8-13 analogs exhibiting species selectivity, stereoselectivity, and superagonism,” J. Biol. Chem. 270: 18359-18366 (Aug. 4, 1995).
Cusack B et al., “Pharmacological studies on novel neurotensin mimetics: discovery of a pharmacologically unique agent exhibiting concentration-dependent dual effects as antagonist and agonist,” Mol. Pharmacol. 44:1036-1040 (1993).
Cusack B et al., “Effects of a novel neurotensin peptide analog given extracranially on CNS behaviors mediated by apomorphine and haloperidol,” Brain Research 856:48-54 (2000).
Fauq AH et al., “Synthesis of (2S)-2-amino-3-(1H-4-indolyl) propanoic acid, a novel tryptophan analog for structural modification of bioactive peptides,” Tetrahedron: Asymmetry 9:4127-4134 (1998).
Huang W and Hanson GR, “Differential effect of haloperidol on release of neurotensin in extrapyramidal and limbic systems,” Eur. J. Pharmacology 332:15-21 (1997).
Jolicoeur FB et al., “Differential neurobehavioral effects of neurotensin and structural analogues,” Peptides 2:171-175 (1981).
Kitabgi P et al., “Neurotensin binding to extraneural and neural receptors: comparison with biological activity and structure-activity relationships,” Molecular Pharmacology 18:11-19 (1980).
Lambert PD et al., Anatomy and mechanisms of neurotensin-dopamine interactions in the central nervous system, Annals New York Academy of Sci. 757:377-389 (1995).
Li X-M et al., “Neurotensin peptides antagonistically regulate postsynaptic dopamine D2 receptors in rat nucleus accumbens: a receptor binding and microdialysis study,” J. Neural. Transm. 102:125-137 (1995).
Morbeck DE et al., “Analysis of hormone-receptor interaction sites using synthetic peptides: Receptor binding regions of the alpha-subunit of human choriogonadotropin,” In: Methods: A Companion to Methods in Enzymology 5:191-200, Academic Press Inc., New York (1993).
Radke JM et al., “Atypical antipsychotic drugs selectively increase neurotensin efflux in dopamine terminal regions,” Proc. Natl. Acad. Sci. USA 95:11462-11464 (Sep. 15, 1998).
Sarhan S et al., “Comparative antipsychotic profiles of neurotensin and a related systemically active peptide agonist,” Peptides 18(8):1223-1227 (1997).
Snijders R et al., “Neurotensin induces catalepsy in mice,” Neuropharmacology 21: 465-468 (1982).
Troxler von Franz, “Praparative verwendung von mannich-basen von hydroxy-indolen als alkylierungsmittel,” Helvetica Chimica Acta, Volumen 51, Fasciculus 6:1214-1224 (1968).
Tyler BM et al., “In vitro binding and CNS effects of novel neurotensin agonists that cross the blood-brain barrier,” Neuropharmacology 38:1027-1034 (1999).
Tyler BM et al., “Evidence for additional neurotensin receptor subtypes: neurotensin analogs that distinguish between neurotensin-mediated hypothermia and antinociception,” Brain Research 792:246-252 (1998).
Tyler-McMahon et al., “Neurotensin: peptide for the next millennium,” Regulatory Peptides 93:125-136 (2000).
Vincent Jean-Pierre et al., “Neurotensin and neurotensin receptors,” TIPS 20:302-309 (1999).

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