Process for the preparation of Tenofovir

Details Process for the preparation of Tenofovir Process for the preparation of Tenofovir

2009-01-12

2011-11-01

Berch, Mark (Department: 1622)

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

Reexamination Certificate

active

08049009

ABSTRACT:
The present invention relates to novel Tenofovir disoproxil hemifumarate salt, which is prepared by dealkylation of Phosphonate esters by using mineral acids followed by esterification and crystallization to give crystalline Tenofovir disoproxil. The Tenofovir disoproxil is further converted to fumarate salts with improved yield.

REFERENCES:
patent: 5733788 (1998-03-01), Bischofberger
patent: 5922695 (1999-07-01), Arimilli et al.
patent: 6465649 (2002-10-01), Gutierrez et al.
patent: 2004/0018150 (2004-01-01), Becker et al.
patent: 2009/0176983 (2009-07-01), Dova et al.
patent: 2009/0270352 (2009-10-01), Dova et al.
patent: 2011/0009368 (2011-01-01), Dova
patent: 2008MU00292 (2009-10-01), None
patent: WO 2008007392 (2008-01-01), None

Affiliated with

Also associated with

Rating

Process for the preparation of Tenofovir does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for the preparation of Tenofovir, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for the preparation of Tenofovir will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4257985