Process for the cyclization of aryl (methylsulfinyl)-methyl keto

Details Process for the cyclization of aryl (methylsulfinyl)-methyl keto Process for the cyclization of aryl (methylsulfinyl)-methyl keto

1975-04-25

1977-03-15

Thomas, Jr., James O.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07D31102

Patent

active

040124223

ABSTRACT:
The invention relates to novel compounds having the formulas I and III: ##STR1## wherein, in formula I, X is -O- or -N-COR wherein R is lower alkyl or aryl, and Z is ##STR2## WHEREIN R' is hydrogen, halogen or alkoxy. The compounds of this invention are prepared by a novel process which involves the cyclization of the corresponding aryl(methylsulfinyl)methyl ketones. The compounds of this invention having formulas I and III are useful in the treatment of hyperacidity and for alleviating allergic manifestations.

REFERENCES:
patent: 3699128 (1972-10-01), Strandtmann et al.
patent: 3699129 (1972-10-01), Strandtmann et al.
patent: 3798240 (1974-03-01), Strandtmann et al.
patent: 3801644 (1974-04-01), Strandtmann et al.
patent: 3850966 (1974-11-01), Cohen et al.
Becker et al., J. Amer. Chem. Soc., 85, 3410 (1963).
Corby et al., J. Amer. Chem. Soc., 84, 866 (1962).

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