Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2008-05-22
2011-10-25
Cook, Lisa (Department: 1641)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S007100, C436S001000, C436S501000, C436S518000, C424S009100, C424S520000, C422S050000, C530S300000, C530S350000
Reexamination Certificate
active
08043824
ABSTRACT:
A method for determining the redox status of a protein sample, the method comprising the steps of: a) contacting the sample with a first label adapted to bind to at least one reduced cysteine group therein; b) contacting the sample with a reducing agent to reduce at least one oxidized cysteine group therein; c) contacting the sample with a second label adapted to bind to any reduced cysteine groups produced in step (b); and d) determining the ratio of the signal from the first label to the signal from the second label wherein the ratio indicates the redox status.
REFERENCES:
Sahaf, B et al. Proceedings of the National Academy of Sciences (USA) 2003, vol. 100, No. 7, pp. 4001-4005.
Nishi, T et al. The Journal of Biological Chemistry, 2002, vol. 277, No. 46, pp. 44548-44556.
Arthur Peter G.
Lipscombe Richard J.
Lui James K.
Cook Lisa
Edward Angell Palmer & Dodge LLP
Emmons Richard B.
Proteomics International Pty Ltd.
Williams Kathleen
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