Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Reexamination Certificate
2001-12-22
2010-06-22
Canella, Karen A (Department: 1643)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
C435S455000, C435S462000, C435S463000, C435S467000
Reexamination Certificate
active
07741077
ABSTRACT:
The present invention generally relates to the fields of genetic engineering and antibody production. In particular, it relates to the generation of genetically modified vertebrate precursor lymphocytes that have the potential to differentiate into more mature lymphoid lineage cells, and to the use thereof for the production of any heterologous antibody or binding protein.
REFERENCES:
patent: 5169939 (1992-12-01), Gefter et al.
patent: 5583033 (1996-12-01), Terstappen et al.
patent: 5874299 (1999-02-01), Lonberg
patent: 6051225 (2000-04-01), Mezes et al.
patent: 6300129 (2001-10-01), Lonberg et al.
patent: 2005/0196755 (2005-09-01), Zauderer et al.
patent: 0546073 (1997-09-01), None
patent: 0605522 (1999-06-01), None
patent: 0585287 (1999-10-01), None
patent: 05-184386 (1993-07-01), None
patent: 10-146194 (1998-06-01), None
patent: 295418 (2000-02-01), None
patent: WO 92/03918 (1992-03-01), None
patent: WO 01/87058 (2001-11-01), None
Green (Journal of Immunological Methods, 1999. 23:11-23).
Zan et al (Immunity, May 2001, vol. 14, pp. 643-653).
Roitt et al, Immunology (text book), 5th Edition, 1998, p. 106.
Austin et al (Human Gene Therapy, Jul. 1, 2001, vol. 12, pp. 1239-1249).
Kawaichi et al (Journal of Biological Chemistry, 1991, vol. 266, pp. 18387-1394).
Abstract of Kim et al (FASEB, 2002, vol. 16, p. A315).
International Search Report, completed Jun. 20, 2002.
Dong Sung An et al, “Lentivirus Vector-Mediated Hematopoietic Stem Cell Gene Transfer of Common Gamma-Chain Cytokine Receptor in Rhesus Macaques”, Journal of Virology, Apr. 2001, pp. 3547-3555.
Anne-Catherine Fluckiger et al, “In Vitro Reconstitution of Human B-Cell Ontogeny: From CD 34+ Multipotent Progenitors to Ig-Secreting Cells”. Blood, vol. 92, No. 12, Dec. 15. 1998, pp. 4509-4520.
Paola Ghia et al, “Ordering of Human Bone Marrow B Lymphocyte Precursors by Single-Cell Polymerase Chain Reaction Analyses of the Rearrangement Status of the Immunoglobulin H and L Chain Gene Loci”, Journal Exp. Med., vol. 184, Dec. 1996, pp. 2217-2229.
M. Duenas et al, “In vitro immunization of naive human B cells yields high affinity immunoglobulin G antibodies as illustrated by phage display”, 1996, Blackwell Science Ltd., Immunology 89, pp. 1-7.
Frederick W. Alt et al, “Ordered rearrangement of immunoglobulin heavy chain variable region segments”, The EMBO Journal, 1984, vol. 3, No. 6, pp. 1209-1219.
Jianzhu Chen et al, “Immunoglobulin gene rearrangement in B cell deficient mice generated by targeted deletion of the JH locus”, International Immunology, 1993, vol. 5, No. 6, pp. 647-656.
Jianzhu Chen et al, “B cell development in mice that lack one or both immunoglobulin light chain genes”, The EMBO Journal, 1993, vol. 12, No. 3, pp. 821-830.
Mike Clark, “Antibody humanization: a case of the ‘Emperor's new clothes’?”, Immunology Today, Aug. 2000, vol. 21, No. 8, pp. 397-402.
Simona Fiorentini et al, “Humanization of an antibody recognizing a breast cancer specific epitope by CDR-grafting”, Immunotechnology 3 (1997) pp. 45-59.
Dianne M. Fishwild et al, “High-avidity human IgGk monoclonal antibodies from a novel strain of minilocus transgenic mice”. Nature Biotechnology. vol. 14, Jul. 1996. pp. 845-851.
J. Kimble Frazer et al, “Immunoglobulins: Structure and Function”, Fundamental Immunology, Fourth Edition, 1999, pp. 37-74.
Michael L. Gallo, et al, “The human immunoglobulin loci introduced into mice: V (D) and J gene segment usage similar to that of adult humans”, Eur. J. lmmunol. 2000, 30: 534-540.
Martin J. Glennie et al, “Clinical trials of antibody therapy”, Immunology Today, Aug. 2000. vol. 21, No. 8, pp. 403-410.
Ulf Grawunder et al, “Induction of sterile transcription from the kl chain gene locus in V (D) J recombinase-deficient progenitor B cells”, International Immunology, Jul. 1995, vol. 7, No. 12, pp. 1915-1925.
Ulf Grawunder et al, “Antigen receptor gene rearrangement”, Current Opinion in Immunology, 1998, 10: pp. 172-180.
Ulf Grawunder et al, “DNA Ligase IV Is Essential for V(D)J Recombination and DNA Double-Strand Break Repair in Human Precursor Lymphocytes”, Molecular Cell, Oct. 1998. vol. 2. pp. 477-484.
L.L. Green et al, “Antigen-specific human monoclonal antibodies from mice engineered with human Ig heavy and light chain YACs”. Nature Genetics, vol. 7, May 1994, pp. 13-21.
Ed Harlow et al, “Chapter 6—Monoclonal Antibodies”, Antibodies, A Laboratory Manual, Cold Spring Harbor Laboratory 1988, pp. 150-173.
Hennie R. Hoogenboom et al, “Natural and designer binding sites made by phage display technology”, Immunology Today, Aug. 2000, vol. 21, No. 8, pp. 371-378.
Hennie R. Hoogenboom et al, “By-passing Immunisation Human Antibodies from Synthetic Repertoires of Germline Vh Gene Segments Rearranged in Vitro”, Journal Molecular Biology, 1992, vol. 227, pp. 381-388.
N. N. Iscove et al, “Complete Replacement of Serum by Albumin, Transferrin, and Soybean Lipid in Cultures of Lipopolysaccharide-Reactive B Lymphocytes”, The Journal of Experimental Medicine, vol. 147, 1978, pp. 923-933.
Aya Jakobovits, “Production of fully human antibodies by transgenic mice”, Cell Genesys Inc., Foster City, USA, Current Opinion in Biotechnology 1995, 6:561-566.
Aya Jakobovits et al, “Production of Antigen-Specific Human Antibodies from Mice Engineered with Human Heavy and Light Chain YACs” Cell Genesys, Inc., Foster City, CA, Annals New York Academy of Sciences, pp. 525-535, 1995, vol. 764.
Matti Kaartinen et al, “Reading of D genes in variable frames as a source of antibody diversity”, Immunology Today, vol. 6, No. 11, 1985, pp. 324-327.
Hajime Karasuyama et al, “Surrogate Light Chain in B Cell Development”, Advances in Immunology, Jan. 1996, vol. 63, pp. 1-41.
John F. Kearney et al, “A New Mouse Myeloma Cell Line That Has Lost Immunoglobulin Expression But Permits the Construction of Antibody-Secreting Hybrid Cell Lines”, The Journal of Immunology, vol. 123, No. 4, Oct. 1979, pp. 1548-1550.
Daisuke Kitamura et al, “Targeted disruption of u chain membrane exon causes loss of heavy-chain allelic exclusion”, Nature, vol. 356, Mar. 12, 1992, pp. 154-156.
Achim Knappik et al, “Fully Synthetic Human Combinatorial Antibody Libraries (HuCAL) Based on Modular Consensus Frameworks and CDRs Randomized with Trinucleotides”, Journal Molecular Biology, 2000, 296, pp. 57-86.
Hiro-Aki Kodama et al, “In Vitro Hemopoiesis Within a Microenvironment Created by MC3T3-G2/PA6 Preadipocytes”, Journal of Cellular Physiology 118:233-240 (1984).
G. Kohler et al, “Derivation of specific antibody-producing tissue culture and tumor lines by cell fusion”, Eur. J. lmmunol. 1976. 6:511-519.
Ralf Kuhn et al, “Advances in gene targeting methods”, Current Opinion in Immunology, 1997, 9: pp. 183-188.
Nils Lonberg et al, “Human Antibodies from Transgenic Mice”, Intern. Rev. Immunol., vol. 13, 1995, pp. 65-93.
Dina Markowitz et al, “A Safe Packaging Line for Gene Transfer: Separating Viral Genes on Two Different Plasmids”, Journal of Virology, Apr. 1988, vol. 62, No. 4, pp. 1120-1124.
Francoise Maxwell et al, “Cloning, Sequence Determination, and Expression in Transfected Cells of the Coding Sequence for the tox 176 Attenuated Diphtheria Toxin A Chain”, Molecular and Cellular Biology, Apr. 1987, vol. 7, No. 4, pp. 1576-1579.
John McCafferty et al, “Phage antibodies: filamentous phage displaying antibody variable domains”, Nature, vol. 348, Dec. 6, 1990, pp. 552-554.
James W. McCarrick III et al, “Positive-negative selection gene targeting with the diphtheria toxin A-chain gene in mouse embryonic stem cells”, Transgenic Research 2, 1993, pp. 183-190.
Fritz Melcher
Grawunder Ulf
Melchers Georg Friedrich
4-Antibody AG
Canella Karen A
Sterne Kessler Goldstein & Fox P.L.L.C.
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