Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Reexamination Certificate
2007-06-08
2010-11-23
Bunner, Bridget E (Department: 1647)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
C530S387300, C530S388100, C530S388150, C435S069100, C435S320100
Reexamination Certificate
active
07838636
ABSTRACT:
The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
REFERENCES:
patent: 5011912 (1991-04-01), Hopp et al.
patent: 5194596 (1993-03-01), Tischer et al.
patent: 5350836 (1994-09-01), Kopchick et al.
patent: 5534409 (1996-07-01), Groner et al.
patent: 5536637 (1996-07-01), Jacobs
patent: 6600019 (2003-07-01), Prayaga et al.
patent: 7368531 (2008-05-01), Rosen et al.
patent: 7411051 (2008-08-01), Rosen et al.
patent: 2007/0224663 (2007-09-01), Rosen et al.
patent: WO-91/04328 (1991-04-01), None
patent: WO-99/66041 (1999-12-01), None
patent: WO0146443 (2001-06-01), None
Wells, Biochemistry, 1990, vol. 29, pp. 8509-8517.
Lazar et al Molecular Cell. Biol., 1988., vol. 8, pp. 1247-1252.
Crandall et al, Journal of Immunology, 2006, vol. 177, pp. 7930-7942.
Jacobs et al., “A genetic selection for isolating cDNAs encoding secreted proteins,”Gene, 198:289-296 (1997).
Anisowicz et al., “A novel protease homolog differentially expressed in breast and ovarian cancer,”Molecular Medicine, 2(5):624-636 (Sep. 1996).
Clark et al., “The potential role for prolactin-inducible protein (PIP) as a marker of human breast cancer micrometastasis,”British Journal of Cancer, 81(6):1002-1008 (May 1999).
desJardins et al, “Prediction of enzyme classification from protein sequence without the use of sequnce similarity,”American Association for Artificial Intelligence, pp. 92-99 (1997).
Everett et al., “Pendred Syndrome is Caused by Mutations in a Putative Sulphate Transporter Gene (PDS),”Nature Genetics17:411-422 (Dec. 1997).
Ferrari et al., “Prospective analysis of prostate-specific markers in pelvic lymph nodes of patients with high-risk prostate cancer,”Journal of the National Cancer Institute, 89:1498-1504 (Oct. 15, 1997).
Gygi et al., “Correlation between protein and mRNA abundance in yeast,”Molecular and Cellular Biology, 19(3):1720-1730 (Mar. 1999).
Hammond et al., “Issues and Barriers to Development of Clinically Useful Tumor Markers: A Development Pathway Proposal,”Semin. Oncol. 29(3):213-221 (Jun. 2002).
Haynes et al., “Proteome analysis: biological assay or data archive?”Electrophoresis, 19:1862-1871 (1998).
Holm, L., “Unification of protein families,”Current Opinion in Structural Biology, 8:372-379 (1998).
Kaufman et al., “Transgenic analysis of a 100-kb human B-globulin cluster-containing DNA fragment propagated as a bacterial artificial chromosome,”Blood94(9):3178-3184 (Nov. 1, 1999).
Maida et al., “Ovarian endometrioid adenocarcinoma with ectopic production of alpha-fetoprotein,”Gynecol. Oncol. 71(1):133-136 (Oct. 1998) (abstract only).
Ngo et al., “Computational Complexity, Protein Structure Prediction, and the Levinthal Paradox,” in Merz and Le Grand (Eds.), The Protein Folding Problem and Tertiary Structure Prediction, Birkhauser Boston, pp. 491-495 (1994).
Palù et al., “In pursuit of new developments for gene therapy of human diseases,”J. Biotech., 68:1-13 (1999).
Pennica et al., “WISPgenes are members of the connective tissue growth factor family that are up-regulated in Wnt-1-transformed cells and aberrantly expressed in human colon tumors,”Proc. Natl. Acad. Sci. USA, 95:14717-14722 (Dec. 1998).
Phillips, A.J., “The challenge of gene therapy and DNA delivery,”J. Pharm. Pharmacol., 53:1169-1174 (May 1, 2001).
Scott et al., “The Pendred Syndrome Gene Encodes a Chloride-iodide Transport Protein,”Nature Genetics21:440-443 (Apr. 1999).
Seffernick et al., “Melamine Deaminase and Atrazine Chlorohydrolase: 98 Percent Identical but Functionally Different,”J. Bacteriology, 183(8):2405-2410 (Apr. 2001).
Vukicevic et al., “Induction of nephrogenic mesenchyme by osteogenic protein 1 (bone morphogenetic protein 7),”PNAS USA93:9021-9026 (Aug. 1996).
Wang et al., “Rapid analysis of gene expression (RAGE) facilitates universal expression profiling,”Nucl. Acids Res., 27(23):4609-4618 (1999).
Wells, J.A., “Additivity of Mutational Effects in Proteins,”Biochemistry, 29(37):8509-8517 (1990).
Witkowski et al., “Conversion of Beta-Ketoacyl Synthase to a Malonyl Decarboxylase by Replacement of the Active-Site Cysteine with Glutamine,”Biochemistry38:11643-11650 (1999).
Irving et al., “Phylogeny of the Serpin Superfamily: Implications of Patterns of Amino Acid Conservation for Structure and Function”, Genome Res., 10:1845-1864, 2000.
Patel et al., “KIf4 and corticosteroids activate an overlapping set of transcriptional targets to accelerate in utero epidermal barrier acquisition”, PNAS, vol. 103, No. 49, 18668-18673, Dec. 5, 2006.
Cheng, S.Y., “Thyroxine-binding globulin precursor (T4-binding globulin),” Swiss-Prot Accession No. P05543, 1996.
Arakawa, et al., “Angiotensinogen precursor,” Swiss-Prot Accession No. P01019, 1991.
Bollen, et al., “Alpha-1-Antitrypsin Precursor (Alpha-1 Protease Inhibitor) (Alpha-1-Antiproteinase),” Swiss-Prot Accession No. P01009, 1996.
Caminos, et al., “Serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12 precursor [Homo sapiens],” Accession NP—776249, 2009.
Rao, et al., “α1-Antitrypsin Is Degraded and Non-Functional in Chronic Wounds But Intact and Functional in Acute Wounds: The Inhibitor Protects Fibronectin from Degradation by Chronic Wound Fluid Enzymes”, The Journal of Investigative Dermatology, vol. 105, No. 4, 572-578, 1995.
Rosen Craig A.
Ruben Steven M.
Wei Ying-Fei
Bunner Bridget E
Hamud Fozia M
Human Genome Sciences Inc.
LandOfFree
Antibodies to HWHGU54 polypeptides does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Antibodies to HWHGU54 polypeptides, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antibodies to HWHGU54 polypeptides will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4246993