Targeting and enhancing RNA-RNA recombination

Details Targeting and enhancing RNA-RNA recombination Targeting and enhancing RNA-RNA recombination

1993-07-09

1999-03-02

Robinson, Douglas W.

Multicellular living organisms and unmodified parts thereof and

Method of introducing a polynucleotide molecule into or...

The polynucleotide alters fat, fatty oil, ester-type wax, or...

4351723, 4352523, 4353201, 536 231, 536 251, A01H 500, C12N 1582, C07H 2102

Patent

active

058774017

ABSTRACT:
A construct formed from a first RNA molecule carrying an antisense insert complementary to a nucleotide sequence in a second target RNA molecule is used to direct crossovers between the first and second RNAs at or near the site of hybridization. The incidence of recombination and the location of recombinant junctions depends on the structure of the recombining RNA molecules and on the stability of the heteroduplex region. The RNA-RNA construct may be provided in double stranded DNA form. The DNA form may be inserted into a vector and used to transform or transfect a host.

REFERENCES:
Gal et al 1991 The EMBO Journal 10 (6):1571-1578.
Bujarski et al. 1986 Genetic recombination between RNA components of a multipartite plant virus, Nature, vol. 321, pp. 528-531.
Nagy et al 1992 (Nov.) Genetic Recombination in Brome Mosaic Virus, Journal of Virology, vol. 66, pp. 6824-6828.
Bujarski et al 1991 Generation and Analysis of Nonhomologous RNA-RNA Recombianants,Journal of Virology,vol. 65,pp.4153-4159.
Bujarski et al Modulation of replication, aminoacylation and adenylation in vitro, The EMBO Journal,vol.5, No.8, 1986,pp.1769-1774.

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