Mice mutant for functional Fc receptors and method of treating a

Details Mice mutant for functional Fc receptors and method of treating a Mice mutant for functional Fc receptors and method of treating a

1994-08-18

1999-03-02

Stanton, Brian R.

Multicellular living organisms and unmodified parts thereof and

Nonhuman animal

4351723, 424 91, 424 92, A61K 4900, C12N 1500, G01N 3100

Patent

active

058773967

ABSTRACT:
Disclosed herein is a non-naturally occurring non-human vertebrate animal incapable of expressing a functional Fc receptor which may optionally be capable of expressing a protein which comprises a domain of a human Fc receptor, as well as DNA encoding such Fc receptor-based proteins. Also disclosed are in vivo methods for identifying proinflammatory agents that depend on a functional Fc receptor, in vivo methods for identifying proinflammatory agents that do not depend on a functional Fc receptor, and both in vivo and in vitro methods of identifying anti-inflammatory agents. Pharmaceutical compositions containing, and methods of treating inflammation with anti-inflammatory agents are also described.

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Bruggemann et al. 1989. Proc. Natl. Acad. Sc., USA. 86:6709-6713.

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