Inhibitors of cathepsin S

Details Inhibitors of cathepsin S Inhibitors of cathepsin S

2009-01-28

2010-06-08

Habte, Kahsay T (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C514S255010, C544S405000, C544S406000

Reexamination Certificate

active

07732449

ABSTRACT:
The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at least one other cathepsin isozyme. The present invention also provides methods for treating a disease state in a subject by selectively inhibiting cathepsin S. More particularly, the present invention provides compounds having Formula 1:wherein Q is an optionally substituted piperazinyl; andA, R5, R6, R7, R8, R9and Ar are substituents.

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Banker, G.S. et al, “Modern Pharmaceutices, 3ed.” Marcel Dekker, New York, 1996, pp. 451 and 596.

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