Des-(Ala.sup.1, Gly.sup.2), Met.sup.11 -SRIF and intermediates

Details Des-(Ala.sup.1, Gly.sup.2), Met.sup.11 -SRIF and intermediates Des-(Ala.sup.1, Gly.sup.2), Met.sup.11 -SRIF and intermediates

1976-01-30

1977-03-15

Gotts, Lewis

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

260 6, 2601125S, 424177, C07C10352, A61K 3700, C08L 8900

Patent

active

040123456

ABSTRACT:
The dodecapeptide H-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Met-Thr-Ser-Cys-OH, its oxidized form, D-Trp.sup.6 analogue and intermediates obtained in their synthesis are described. These dodecapeptides inhibit the secretion of the hormone somatotropin (growth hormone).

REFERENCES:
B520,514, Mar. 1976, Sarantakis, 260/112.5 S.

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