Nitrooxyderivatives of carvedilol and other beta blockers as...

Details Nitrooxyderivatives of carvedilol and other beta blockers as... Nitrooxyderivatives of carvedilol and other beta blockers as...

2004-12-01

2010-11-02

Havlin, Robert (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C514S411000

Reexamination Certificate

active

07825263

ABSTRACT:
The present invention relates to β-adrenergic blockers nitrooxyderivatives of general formula (I):in-line-formulae description="In-line Formulae" end="lead"?A-(Y—ONO2)sin-line-formulae description="In-line Formulae" end="tail"?and enantiomers and diastereoisomers and pharmaceutically acceptable salts thereof, pharmaceutical compositions containing them and their use for the treatment of hypertension, cardiovascular diseases, glaucoma, migraine headache and vascular diseases.

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CAPLUS abstract of GB 707293.
Yamamoto et al., Exper. Biol. and Medicine, 225 (3): p. 200-206 (2000).
Jayachandran et al., “Up-regulation of endothelial nitric oxide synthase through beta2-adrenergic receptor: The role of a beta-blocker with NO-releasing action”, Biochemical and Biophysical Research Communications, 2001, pp. 589-594, vol. 280, No. 3.

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