Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2005-09-12
2010-06-01
Andres, Janet L. (Department: 1625)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S437000, C514S454000, C514S455000, C546S101000, C549S026000, C549S027000, C549S280000
Reexamination Certificate
active
07728001
ABSTRACT:
The invention provides novel compounds of formula I:that are opioid receptor ligands. The invention also provides pharmaceutical compositions comprising such compounds as well as methods for treating diseases associated with opioid receptor function by administering such compounds to a mammal in need of treatment. The invention also provides an improved method for isolating intermediate materials useful for obtaining compounds of formula I.
REFERENCES:
patent: WO 2005/089745 (2005-09-01), None
Beguin, Cecile et al., “Synthesis and in vitro pharmacological evaluation of salvinorin A analogues modified at C(2)”,Bioorganic&Medicinal Chemistry Letters, vol. 15, 2761-2765 (2005).
Brinner, Kristin M. et al., “Potent 4-aminopiperidine based antimalarial agents”,Bioorganic&Medicinal Chemistry Letters, vol. 15, 345-348, (2005).
Chavkin, Charles et al., “Salvinorin A, an Active Component of the Hallucinogenic SageSalvia divinorumis a Highly efficacious k-Opioid Receptor Agonist: Structural and Functional Considerations”,The Journal of Pharmacology and Experimental Therapeutics, vol. 308, 1197-1203, (2004).
Harding, Wayne W. et al., “Neoclerodane Diterpenes as a Novel Scaffold for u Opioid Receptor.Ligands”,J. Med. Chem., vol. 48, 4765-4771 (2005).
Harding, Wayne W. et al., “Salvinicins A and B, New Neoclerodane Diterpenes fromSalvia divinorum”, Org. Lett., vol. 7, No. 14, 3017-3020, (2005).
Koreeda, Masato et al., “The Absolute Stereochemistry of Salvinorins”,Chemistry Letters, 2015-2018, (1990).
Lee, David Y. W. et al., “Synthesis and in vitro pharmacological studies of new C(2) modified salvinorin A analogues”,Bioorganic&Medicinal Chemistry Letters, vol. 15, 3744-3747, (2005).
Sarma, A. S. et al., “Proton and carbon-13NMR studies of trans-cletrodane diterpenoids and congerers: stereochemical implications and certain correlations with cis-clerodanes”, Indian Journal of Chemistry, Abstract, (1985).
Tidgewell, Kevin et al., A facile method for the preparation of deuterium labeled salvinorin A: synthesis of [ 2,2,2-2H3]-salvinorin A, Biorganic & Medicinal Chemistry Letters, vol. 14, 5099-5102, (2004).
Valdes, Leander J. III et al., “Salvinorin C, a New Neoclerodane Diterpene from a Bioactive Fraction of the Hallucinogenic Mexican MintSalvia divinorum”, Organic Letters, vol. 3, No. 24, 3935-3937, (2001).
Valdes, Leander J. III et al. Divinorin A, a Psychotropic Terpenoid, and Divinorin B from the Hallucinogenic Mexican MintSalvia divinorum, J. Org. Chem., vol. 49, 4716-4721, 1984.
Munro, Thomas A., et al., Studies toward the Pharmacophore of Salvinorin A, a Potent k Opioid Receptor Agonist,J. Med. Chem., vol. 48, 345-348, 2005.
PCT International Search Report, PCT/US2005/032505.
Tidgewell, Kevin, “Herkinorin Analogues with Differential β-Arrestin-2 Interactions”,J. Med. Chem., vol. 51, 2421-2431 (2008).
Butelman, Eduardo R, “The effects of herkinorin, the first μ-selective ligand from salvinorin A-derived scaffold, in a neuroendocrine biomarker assay in non-human primates”,Journal of Pharmacology and Experimental Therapeutics, 1-25, (Jul. 1, 2008).
Tidgewell, Kevin, “Synthesis of Salvinorin A analogues as optoid receptor probes”,J. Nat. Prod. 69, 914-918 (2006).
Prisinzano Thomas
Rothman Richard Brian
Andres Janet L.
Covington Raymond
University of Iowa Research Foundation
Viksnins Harris & Padys PLLP
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