Nitrogen-containing heterocyclic derivatives, medicinal...

Details Nitrogen-containing heterocyclic derivatives, medicinal... Nitrogen-containing heterocyclic derivatives, medicinal...

2003-12-19

2010-02-02

McIntosh, III, Traviss C (Department: 1623)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C514S025000, C514S027000, C536S004100, C536S017200, C536S017300, C536S017400, C536S018100

Reexamination Certificate

active

07655633

ABSTRACT:
The present invention provides nitrogen-containing heterocyclic derivatives represented by the general formula:wherein X1represents N or CR1; X2represents N or CR2; X3represents N or CR3; X4represents N or CR4; and with the proviso that one or two of X1to X4represent N; R represents optionally substituted C3-8cycloalkyl, optionally substituted C6-10aryl, etc.; R1to R4represent H, a halogen atom, etc.) or pharmaceutically acceptable salts thereof, or prodrugs thereof, which exert an excellent inhibitory activity in human SGLT2 and are useful as agents for the prevention or treatment of a disease associated with hyperglycemia such as diabetes, diabetic complications, obesity or the like, pharmaceutical compositions comprising the same, and medicinal uses thereof.

REFERENCES:
patent: 7271153 (2007-09-01), Nishimura et al.
patent: 2002/0111315 (2002-08-01), Washburn et al.
patent: 2005/0049203 (2005-03-01), Nishimura et al.
patent: 1213296 (2002-06-01), None
patent: WO 01/74834 (2001-10-01), None
patent: WO03/000712 (2003-01-01), None
patent: WO 03/000712 (2003-01-01), None
Adachi et al., “T-1095, a Renal Na+-Glucose Transport Inhibitor”, Metabolism, vol. 49 (8) 2000, 990-995.

Affiliated with

Also associated with

Rating

Nitrogen-containing heterocyclic derivatives, medicinal... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Nitrogen-containing heterocyclic derivatives, medicinal..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Nitrogen-containing heterocyclic derivatives, medicinal... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4233946