Molecular complex and control-release of alpha hydroxyacids

Details Molecular complex and control-release of alpha hydroxyacids Molecular complex and control-release of alpha hydroxyacids

1997-04-16

1999-03-02

Weddington, Kevin E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Radical -xh acid, or anhydride, acid halide or salt thereof...

514 31, 514 54, 514178, 514256, 514383, 514419, 514458, 514460, 514562, 514566, 514574, A61K 3119, A61K 3170, A61K 31715, A61K 3156

Patent

active

058772120

ABSTRACT:
Compositions comprising an alpha hydroxyacid or related acid and organic complexing agent having a molecular weight ranging preferably between about 100 and about 600 can form a control-release molecular complex. Such complexing agent preferably possesses one or more amino group in addition to other groups with unshared electrons such as hydroxyl, carbonyl, amido, ester and alkoxyl groups in the same molecule. Such functional groups are capable of forming multiple intermolecular hydrogen bonds with the hydroxyl groups of a free alpha hydroxyacid or related acid. The complexing agents include amino acid esters, non-amphoteric amino acid amides, aminosaccharides, aminoalditols and aminocyclitols.

REFERENCES:
patent: 3879537 (1975-04-01), Van Scott et al.
patent: 3920835 (1975-11-01), Van Scott et al.
patent: 4363815 (1982-12-01), Yu et al.
patent: 5091171 (1992-02-01), Yu et al.
patent: 5425938 (1995-06-01), Znaiden et al.
Chemical Abstracts (126: 268321) Marianos et al. 1997.

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