Treatment of hepatic and renal disorders with mixed salts of ess

Details Treatment of hepatic and renal disorders with mixed salts of ess Treatment of hepatic and renal disorders with mixed salts of ess

1981-09-08

1982-10-05

Trousof, Natalie

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

424317, 424319, A61K 31195, A61K 31415

Patent

active

043528147

ABSTRACT:
Novel compounds are prepared by reacting essential or semi-essential amino acids with nitrogen-free analogues thereof, particularly alpha-keto and/or alpha-hydroxy analogues. The mixed salt reaction products are precursors of essential and semi-essential amino acids in the body, and mixtures of the salts are useful in the treatment of renal and hepatic disorders characterized by protein intolerance leading to deficiencies of various essential and semi-essential amino acids in the body. They may also be useful in the treatment of nitrogen wasting disorders and protein malnutrition. The novel compounds are generally far more palatable and soluble in aqueous solutions than the individual essential or semi-essential amino acids, nitrogen-free analogues thereof, or simple mixtures of these.

REFERENCES:
patent: 2457820 (1949-01-01), Howe et al.
patent: 3441650 (1969-04-01), Georges et al.
patent: 3764703 (1973-10-01), Bergstrom et al.
Richards et al., Lancet, pp. 845-849 (1967).
Reidman, J. Clinical Invest., vol. 50, pp. 90-96 (1971).
Walser, Chem. Abst., vol. 81, #54452q (1974).
Sapir et al., J. Clinical Invest., vol. 54, pp. 974-980 (1974).

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