Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2005-01-19
2010-11-02
Shibuya, Mark L (Department: 1641)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S007800, C435S007920, C435S007930, C435S007940, C436S518000, C436S536000, C436S541000, C436S175000, C436S178000, C530S388250, C530S388260, C530S389100, C530S389300, C530S391100, C530S391300
Reexamination Certificate
active
07824876
ABSTRACT:
A bioaffinity assay for quantitative determination in a sample of free PAPP-A, defined as the pregnancy associated plasma protein A (PAPP-A) that is not complexed to the proform of major basic protein (proMBP), where free PAPP-A is determined either i) as a calculated difference between measured total PAPP-A and measured PAPP-A complexed to proMBP, or ii) by a direct bioaffinity assay measuring only free PAPP-A. Also disclosed is a method for diagnosing an acute coronary syndrome in a person by using as marker either free PAPP-A as such or a ratio free PAPP-A/total PAPP-A, free PAPP-A/PAPP-A complexed to proMBP, or PAPP-A complexed to proMBP/total PAPP-A.
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Pettersson Kim
Qin Qiu-Ping
Grun James L
Lydon James C.
Shibuya Mark L
Turun Yliopisto
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