Metal radionuclide chelating compounds for improved chelation ki

Details Metal radionuclide chelating compounds for improved chelation ki Metal radionuclide chelating compounds for improved chelation ki

1990-09-27

1991-12-24

Maples, John S.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

534 10, 534 14, A61K 4902, C07F 1300

Patent

active

050750992

ABSTRACT:
The present invention provides metal chelating compounds, to chelates and chelate-targeting agent conjugates formed from the chelating compounds, and to methods for making and using these compositions. The chelating compounds incorporate two nitrogen atoms and three sulfur atoms ("N.sub.2 S.sub.3 "), two nitrogen atoms and four sulfur atoms ("N.sub.2 S.sub.4 "), or three nitrogen atoms and three sulfur atoms ("N.sub.3 S.sub.3 "). Metals, and metal oxides, capable of being chelated by the compounds include those that are radionuclides, such as .sup.99m Tc and .sup.186/188 Re.
The targeting agent portion of the chelate-targeting agent conjugates provided includes antibodies, peptides, hormones, enzymes and biological response modifiers. Methods for making the conjugates are provided and encompass the addition of a metal, or metal oxide, to a chelating compound prior to attachment to a targeting agent as well as subsequent to the attachment.
Another aspect of the invention provides kits for producing chelate-targeting agent conjugates for radiopharmaceutical use.
An additional aspect of the invention provides methods for using the chelate-targeting agent conjugates for diagnostic and therapeutic purposes, such as detection of a target site and delivery of a radionuclide to the site, respectively.

REFERENCES:
patent: 4444690 (1984-04-01), Fritzberg
patent: 4615876 (1986-10-01), Troutner et al.
patent: 4638051 (1987-01-01), Burns et al.
patent: 4666697 (1987-05-01), Takahashi et al.
patent: 4670545 (1987-05-01), Fritzberg et al.
patent: 4673562 (1987-06-01), Davison et al.
patent: 4678667 (1987-07-01), Meares et al.
patent: 4861869 (1989-08-01), Nicolotti et al.
B. Bubeck et al., "Clinical Comparison of I-131 o-Iodohippurate with Tc-99m Co.sub.2 -DADS-A and Tc-99m MAG.sub.3 by Simultaneous Double Tracer Measurement", Nuc., Compact 17:135-138, 1986.
C. Muller-Suur et al., "Clearance and Renal Extraction of a New Renal Scanning Agent: Technetium-99m MAG.sub.3 in Comparison to Hippurate (OIH) and EDTA", J. Nucl. Med. 27:572, 1986.
Alan R. Fritzberg et al., "Synthesis and Biological Evaluation of Technetium-99m MAG.sub.3 as a Hippuran Replacement", J. Nucl. Med. 27:111-116, 1986.
Ban An Khaw et al., "Technetium-99m Labeling of Antibodies to Cardiac Myosin Fab and to Human Fibrinogen", J. Nucl. Med. 23:1011-1019, 1982.
D. L. Nosco et al., "Characterization of the New (Tc-99m) Dynamic Renal Imaging Agent: (Tc-99m)MAG.sub.3 ", J. Nucl. Med. 27:939, 1986.
A. Taylor, Jr. et al., "Preliminary Evaluation of Technetium-99m Mercaptoacetyltriglycine (MAG.sub.3) as a Replacement for Iodine-131 OIH", J. Nucl. Med. 27:571-572, 1986.

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