Vitamin D derivative with substituent at the 2.beta.-position

Details Vitamin D derivative with substituent at the 2.beta.-position Vitamin D derivative with substituent at the 2.beta.-position

1996-09-03

1999-03-02

Dees, Jose G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

9,10-seco- cyclopentanohydrophenanthrene ring system doai

552653, A61K 3159, C07C40100

Patent

active

058771689

ABSTRACT:
A 1.alpha.-hydroxy-vitamin D derivative represented by formula (I): ##STR1## wherein R.sub.1 represents a hydrogen atom or a hydroxyl group; and R.sub.2 represents a straight-chain or branched lower alkyl, lower alkenyl or lower alkynyl group, which is substituted with a hydroxyl group, a halogen atom, a cyano group, a lower alkoxy group, an amino group or an acylamino group,
is disclosed. The compound exhibits calcium metabolism regulating activity and differentiation stimulating activity on tumor cells, etc. and is useful as a treating agent for diseases caused by abnormal calcium metabolism, such as osteoporosis and osteomalacia, or as an antitumor agent.

REFERENCES:
patent: 4011250 (1977-03-01), Ishiwaka et al.
patent: 5389622 (1995-02-01), Posner et al.
patent: 5661140 (1997-08-01), DeLuca et al.
Gary H. Posner et al, Stereocontrolled Total Synthesis of Calcitriol . . . Drug J.Org. Chem. vol. 59, pp. 7855-7861, 1994.

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