Recombinant antigens for the detection of coxiella burnetii

Chemistry: molecular biology and microbiology – Vector – per se

Reexamination Certificate

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Reexamination Certificate

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07824909

ABSTRACT:
The invention relates to a method for the detection of prior exposure toCoxiella. burnetiiinfection by antibody-based assays using recombinant, immunodominantC. burnetiipolypeptides. The invention also relates to the design of biotin or His-taggedC. burnetiiproteins useful in the antibody-based assays as standardized antigen reagents.

REFERENCES:
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Hedrick, Immunity, 21:607-615, 2004.
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Greenspan et al. (Nature Biotechnology 7:936-937, 1999).
Uhaa et al. (J. Clin. Microbiol., 32:1560-1565, 1994).
Abbas et al. (Cellular and Molecular Immunology, 3rd ed., WB Saunders, 1997, see p. 9).
Murray et al. Medical Microbiology, 4th Ed. 2002 see p. 418.

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