Polymorphs of atovaquone and process of preparation thereof

Details Polymorphs of atovaquone and process of preparation thereof Polymorphs of atovaquone and process of preparation thereof

2004-07-16

2010-12-07

Krass, Frederick (Department: 1612)

Organic compounds -- part of the class 532-570 series

Organic compounds

Cyclohexadiene having atoms double bonded directly at the 1-...

C552S299000, C514S682000

Reexamination Certificate

active

07847112

ABSTRACT:
Novel crystalline forms of antiPneumocystis cariniicompound (2-[4-(4-Chlorophenyl)cyclohexyl]-3-hydroxy-1,4-naphthoquinone) commonly known as Atovaquone and methods for producing the same is disclosed herein. This also provides pharmaceutical compositions comprising the said polymorphs of Atovaquone and method of treatingPneumocystis cariniipneumonia, the method comprising administering to a warm blooded animal an effective amount of a product-by-process composition of matter comprising polymorphic forms of Atovaquone.

REFERENCES:
patent: 2553647 (1951-05-01), Fieser et al.
patent: 4981874 (1991-01-01), Latter et al.
patent: 5856362 (1999-01-01), Hudson
patent: 0123238 (1984-10-01), None
Louis F. Fieser, et al, Napthoquinone Antimalarials. IV-XI. Synthesis, 70 J. Am. Chem. Soc. 3174, 3188-91 (1948).

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