Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2004-09-06
2010-06-08
Haq, Shafiqul (Department: 1641)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C436S525000, C436S528000, C436S532000, C436S539000
Reexamination Certificate
active
07732158
ABSTRACT:
This invention provides a method to detect analyte which comprises preparing fine particles which have a chargeable group in their core and a hydrophilic polymer chain in their shell; obtaining an agglutinated matter by forming a biologically specific bond between a specific residue on the surface of fine particles and analyte, and by simultaneously forming a bond by the electrostatic interaction between impure protein and said particles; and subsequently cleaving only the latter bond by raising ionic intensity. Thus, this invention provides a method to detect analyte with rapidity and high sensitivity with use of agglutination reaction.
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Ishii Takehiko
Kataoka Kazunori
Nagasaki Yukio
Takahashi Tadahito
Haq Shafiqul
Japan Science and Technology Agency
Wenderoth , Lind & Ponack, L.L.P.
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