Imidazolopyrazole derivatives useful as selective androgen...

Details Imidazolopyrazole derivatives useful as selective androgen... Imidazolopyrazole derivatives useful as selective androgen...

2007-02-01

2010-02-02

Anderson, Rebecca L (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S407000, C548S303100, C548S360500

Reexamination Certificate

active

07655683

ABSTRACT:
The present invention is directed to novel imidazolopyrazole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by the androgen receptor.

REFERENCES:
patent: 2006/0211756 (2006-09-01), Zhang et al.
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patent: WO 03/096980 (2003-11-01), None
patent: WO 2005/087232 (2005-09-01), None
patent: WO 2005/089118 (2005-09-01), None
International Search Report for PCT International Application No. PCT/US2007/061436 dated May 21, 2007.
Basaria, S. et al.: “Anabolic-Androgenic Steroid Therapy in the Treatment of Chronic Diseases”; The J. of Clin. Endocrin. & Metab. (2001) 86(11): 5108-5117.
Newling, D.W.W.: “Anti-androgens in the treatment of prostate cancer”; British J. of Urology (1996) 77: 776-784.
Shahidi, N.T., MD: “A Review of the Chemistry, Biological Action, and Clinical Applications of Anabolic-Androgenic Steroids”; Clinical Therapeutics (2001) 23(9): 1355-1390.
Zhang, X. et al.: “Synthesis and SAR of novel hydantoin derivatives as selective androgen receptor modulators”; Elsevier, Bioorganic & Med. Chem. Letters (2006) 16: 5763-5766.
Zhang, X. et al.: “Serendipitous discovery of novel imidazolopyrazole scaffold as selective androgen receptor modulators”; Elsevier, Bioorganic & Med. Chem. Letters (2007) 17: 439-443.

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