Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing – Animal or plant cell
Reexamination Certificate
2002-11-08
2010-06-01
Saunders, David A. (Department: 1644)
Drug, bio-affecting and body treating compositions
Whole live micro-organism, cell, or virus containing
Animal or plant cell
C424S093700, C435S002000, C435S372000, C604S004010, C604S006030, C604S006080
Reexamination Certificate
active
07727523
ABSTRACT:
Methods are provided for suppressing the immune system response in recipients of transplanted organs, tissues or cells. An extracorporeal quantity of blood from the intended transplant recipient is treated to induce monocytes contained in the blood to differentiate and form dendritic cells. The maturation of the dendritic cells is truncated at a stage where the dendritic cells can inactivate T cell clones which would otherwise generate an undesired immune system response. The immature dendritic cells can be directly administered to the transplant recipient, or the dendritic cells can be co-incubated with the bone marrow or stem cell preparation, prior to transplantation, in order to suppress or eliminate anti-recipient donor T cells contaminating the bone marrow or stem cell preparation. The methods can be used to suppress graft versus host disease in recipients of transplanted bone marrow or stem cells, or to suppress rejection of transplanted organs or tissue.
REFERENCES:
patent: 4321918 (1982-03-01), Clark
patent: 4838852 (1989-06-01), Edelson et al.
patent: 6524855 (2003-02-01), Edelson et al.
patent: 6596275 (2003-07-01), Bartholeyns et al.
patent: 6602709 (2003-08-01), Albert et al.
patent: 6800300 (2004-10-01), Miller et al.
patent: 2002/0051771 (2002-04-01), Bolton et al.
patent: 2002/0114793 (2002-08-01), Edelson et al.
patent: 2003/0133914 (2003-07-01), Edelson et al.
patent: 2005/0084966 (2005-04-01), Edelson et al.
patent: WO 97/34472 (1997-09-01), None
patent: WO 00/62818 (2000-10-01), None
Greinix, et al. Successful Use of Extracorporeal Photochemotherapy in the Treatment of Severe Acute and Chronic Graft-Versus-Host Disease, Blood, vol. 92, No. 9, 1998, pp. 3098-3104.
Greinix, et al. Extracorporeal Photochemotherapy in the Treatment of Severe Steroid-Refractory Acute Graft-Versus-Host Disease: A Pilot Study, Blood, vol. 96, No. 7,, 2000, pp. 2426-2431.
Barr, et al. Photopheresis for the Prevention of Rejection in Cardiac Transplantation, The New England Journal of Medicine, 1998, pp. 1744-1751.
Yamane, et al. Suppression of Anti-Skin-Allograft Response by Photodamaged Effector Cells—The Modulating Effects of Prednisolone and Cyclophosphamide, Transplantation, 1992, pp. 119-124.
Perez, Induction of a Cell-Transferable Suppression of Alloreactivity by Photodamaged Lymphocytes, Transplantation, 1992, pp. 896-903.
Perez, DNA Associated with the Cell Membrane is Involved in the Inhibition of the Skin Rejection Response in the Inhibition of the Skin Rejection Response Induced by Infusions of Photodamaged Alloreactive Cells that Mediate Rejection of Skin Allograft, Photochemistry and Photobiology, vol. 55, No. 6, 1992, pp. 839-849.
Cohen, et al. CD4+CD25+Immunoregulatory T Cells: New Therapeutics for Graft-Versus-Host Disease, The Rockefellar University Press, vol. 196, No. 3, Aug. 5, 2002, pp. 401-406.
Chambers, The expanding world of co-stimulation: the two-signal model revised, Trends in Immunology, vol. 22, No. 4, Apr. 2001, pp. 217-223.
Hoffmann, et al. Donor-type CD4+CD25+ Regulatory T Cells Suppress Lethal Acute Graft-Versus-Host Disease after Allogeneic Bone Marrow Transplantation, The Rockefeller University Press, vol. 196, No. 3, Aug. 5, 2002, pp. 389-399.
Rossi, M. et al., Plasmacytoid Dendritic Cells: Do They Have a Role in Immune Responses After Hematopoietic Cell Transplantation? Human Immunology Dec. 2002, vol. 63, No. 12, pp. 1194-1200.
Heshmati, F. Mechanisms of Action of Extracorporeal Photochemotherapy Transfusion and Apheresis Science Aug. 2003, vol. 29, No. 1, pp. 61-70, Abstract.
Ying G et al: “Tricyclic antidepressants prevent the differentiation of monocytes into macrophage-like cells in vitro.”Cel Biol Toxicol. 2002; 18(6):425-37.
Beaudoin L et al: “NKT cells inhibit the onset of diabetes by impairing the development of pathogenic T cells specific for pancreatic beta cells.”Immunity. Dec. 2002;17(6):725-36.
Kitazawa T et al: “Studies on delayed systemic effects of ultraviolet B radiation on the induction of contact hypersensitivity, 3. Dendritic cells from secondary lymphoid organs are deficient in interleukin-12 production and capacity to promote activation and differentiation of T helper type 1 cells.”Immunology. Feb. 2000;99(2):296-304.
Tang A et al: “Inhibition of epidermal Langerhans cell function by low dose ultraviolet B radiation. Ultraviolet B radiation selectively modulates ICAM-1 (CD54) expression by murine Langerhans cells.”J Immunol. May 15, 1991;;146(10):3347-55.
Shen W et al: “Ganglioside GD1a impedes lipopolysaccharide-induced maturation of human dendritic cells.”Cell Immunol. Dec. 2002;220(2):125-33.
Lateef Z et al: “Orf virus-encoded interleukin-10 inhibits maturation, antigen presentation and migration of murine dendritic cells.”J Gen Virol. May 2003;84(Pt 5):1101-9.
Shurin MR et al: “Inhibition of CD40 expression and CD-40-mediated dentritic cell function by tumor-derived IL10.”Int J Cancer. Sep. 1, 2002;101(1):61-8.
Semnani RT et al: “Filarial antigens impair the function of human dendritic cells during differentiation.”Infect Immun. Sep. 2001;69(9):5813-22.
Chung F: “Anti-inflammatory cytokines in asthma and allergy: interleukin-10, interleukin-12, interferon-gamma.”Mediators Inflamm. Apr. 2001;10(2):51-9.Links.
Hackstein H et al: “Aspirin inhibits in vitro maturation and in vivo immunostimulatory function of murine myeloid dentritic cells.”J Immunol. Jun. 15, 2001;166(12):7053-62.
Komi J et al: “Non-steroidal anti-oestrogens inhibit the differentiation of synovial macrophages into dendritic cells.”Rheumatology(Oxford) Feb. 2001;40(2):185-91.
Moore KW et al: “Interleukin-10 and the interleukin-10 receptor.”Annu Rev Immunol. 2001;19:683-765.
Bernstein SH et al: “A randomized phase II study of BB-10010: a variant of human macrophage inflammatory protein-1 alpha for patients receiving high-dose etoposide and cyclophosphamide for malignant lymphoma and breast cancer.”BR J Haematol. Dec. 1997;99(4):888-95.
Askenase PW et al: “Gamma delta T cells in normal spleen assist immunized alpha beta T cells in the adoptive cell transfer of contact sensitivity. Effect of Bordetella pertussis, cyclophosphamide, and antibodies to determinants on suppressor cells.”J Immunol. Apr. 15, 1995;154(8):3644-53.
De Smedt T et al: “Effect of interleukin-10 on dendritic cell maturation and function.”Eur J Immunol. May 1997;27(5):1229-35.
Hirohata S: “Suppression of human B cell responsiveness by CD4+ T cells does not involve CD95-CD95 ligand interactions.”Cell Immunol. Nov. 1, 1997;181(2):182-91.
Estry DW et al: “A comparison of the fibrinogen receptor distribution on adherent platelets using both soluble fibrinogen and fibrinogen immobilized on gold beads.”Eur J Cell Biol. Apr. 1991;54(2):196-210.
Blank K et al: “Self-immobilizing recombinant antibody fragments for immunoaffinity chromatography: generic, parallel, and scalable protein purification.”Protein Expr Purif. Mar. 2002;24(2):313-22.
Garlie NK et al: “T cells activated in vitro as immunotherapy for renal cell carcinoma: characterization of 2 effector T-cell populations.”J Urol. Jul. 2001;166(1):299-303.
Foger N. et al: “CD44 supports T cell proliferation and apoptosis by apposition of protein kinases.”Eur J Immunol. Oct. 2000;30(10):2888-99.
Hanau D et al: “A method for the rapid isolation of human epidermal Langerhans cells using immunomagnetic microspheres.”J Invest Dermatol. Sep. 1988;91(3):274-9.
Thomas R et al: “Human peripheral blood dendritic cell subsets. Isolation and characterization of precursor and mature antigen-presenting cells.”J. Immunol. Nov. 1, 1994;153(9):4016-28.
Yanagihara S et al: “EBI1/CCR7 Is a New Member of Dendritic Cell Chemokine Receptor That is Up-Regulated Upon Maturation.”The Journal of Immunology1998, 161: 3096-3102.
Li B et al: “
Berger Carole
Edelson Richard Leslie
Girardi Michael
McCarter & English LLP
Saunders David A.
Yale University
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