siRNA targeting transient receptor potential cation channel,...

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

Reexamination Certificate

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C536S023100, C514S04400A

Reexamination Certificate

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07655789

ABSTRACT:
Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed including those directed to nucleotide sequences for TRPV1.

REFERENCES:
patent: 6001992 (1999-12-01), Ackermann
patent: 6111086 (2000-08-01), Scaringe
patent: 6172216 (2001-01-01), Bennett et al.
patent: 6291642 (2001-09-01), Weinstein
patent: 6506559 (2003-01-01), Fire
patent: 6566127 (2003-05-01), Pavco
patent: 6965025 (2005-11-01), Gaarde et al.
patent: 6994979 (2006-02-01), Reed
patent: 7022831 (2006-04-01), Reed
patent: 7022837 (2006-04-01), Harding
patent: 7157570 (2007-01-01), Yen
patent: 2002/0081578 (2002-06-01), Plowman et al.
patent: 2002/0086321 (2002-07-01), Craig
patent: 2002/0086356 (2002-07-01), Tuschl et al.
patent: 2002/0150945 (2002-10-01), Finney et al.
patent: 2003/0087259 (2003-05-01), Clancy et al.
patent: 2003/0105051 (2003-06-01), McSwiggen
patent: 2003/0143732 (2003-07-01), Fosnaugh
patent: 2003/0157030 (2003-08-01), Davis et al.
patent: 2003/0228597 (2003-12-01), Cowsert
patent: 2004/0029275 (2004-02-01), Brown et al.
patent: 2004/0054155 (2004-03-01), Woolf et al.
patent: 2004/0063654 (2004-04-01), Davis et al.
patent: 2004/0077574 (2004-04-01), Klinghoffer
patent: 2004/0101857 (2004-05-01), Ward
patent: 2004/0180357 (2004-09-01), Reich et al.
patent: 2004/0192629 (2004-09-01), Xu et al.
patent: 2004/0204380 (2004-10-01), Ackermann
patent: 2004/0219671 (2004-11-01), McSwiggen
patent: 2004/0248296 (2004-12-01), Beresford
patent: 2004/0248299 (2004-12-01), Jayasena et al.
patent: 2004/0259247 (2004-12-01), Tuschl et al.
patent: 2005/0048529 (2005-03-01), McSwiggen
patent: 2005/0107328 (2005-05-01), Wyatt
patent: 2005/0130181 (2005-06-01), McSwiggen
patent: 2005/0176025 (2005-08-01), McSwiggen et al.
patent: 2005/0181382 (2005-08-01), Zamore et al.
patent: 2005/0186586 (2005-08-01), Zamore et al.
patent: 2005/0227935 (2005-10-01), McSwiggen
patent: 2005/0239731 (2005-10-01), McSwiggen et al.
patent: 2005/0245475 (2005-11-01), Khvorova
patent: 2006/0286575 (2006-12-01), Farrell
patent: 2007/0031844 (2007-02-01), Khvorova et al.
patent: 2007/0254850 (2007-11-01), Lieberman
patent: WO9800532 (1998-01-01), None
patent: WO0020645 (2000-04-01), None
patent: WO0021559 (2000-04-01), None
patent: WO/0076497 (2000-12-01), None
patent: WO 0244321 (2002-06-01), None
patent: WO03035869 (2003-05-01), None
patent: WO03035870 (2003-05-01), None
patent: WO03070897 (2003-08-01), None
patent: WO03070969 (2003-08-01), None
patent: WO03646625 (2003-08-01), None
patent: WO03072704 (2003-09-01), None
patent: WO2004031237 (2004-04-01), None
patent: WO2004046324 (2004-06-01), None
patent: WO2004048511 (2004-06-01), None
patent: WO2004090105 (2004-10-01), None
patent: WO2005001043 (2005-01-01), None
patent: WO2005078095 (2005-08-01), None
patent: WO2005089224 (2005-09-01), None
patent: WO2005117991 (2005-12-01), None
patent: WO2006015389 (2006-02-01), None
patent: WO2006110813 (2006-10-01), None
Genbank Accession No. NM—018727 [online]. [retrieved Oct. 11, 2008]. Retrieved from the Internet: <http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nuccore$id=117306160>.
Elbashir, et al. (2001) Functional Anatomy of siRNAs for Mediating Efficient RNAI inDrosophila melanogaster Embryo lysate. The EMBO Journal, v.20(23):6877-88.
Elbashir, et al. (2002) Analysis of Gene Function in Somatic Mammalian Cells Using Small Interfering RNAS. Methods, v.26:199-213.
Bass, B.L. (2001) The Short Answer. Nature, v.411:428-9.
Grunweller, et al. (Jun. 15, 2003) Comparison of Different Antisense Strategies in Mammalian Cells Using Locked Nucleic Acids, 2′-O- Methyl RNA, Phosphorothioates and Small Interfering RNA. Nucleic Acids Research, v.31(12):3185-93.
Cherry, J.M. (2000) Computer Manipulation of DNA and Protein Sequences. Current Protocols in Molecular Biology, Unit 7.7: 1-23.
Vickers, et al., Efficient Reduction of Target RNAs by Small Interfering RNA and RNase H-dependent Antisense Agents, Feb. 2003, The Journal of Biological Chemistry, vol. 278, pp. 7108-7118.
Zhang et al., Physical and Functional Interaction between Myeloid Cell Leukemia 1 Protein (MCL1) and Fortilin, 2002, The Journal of Biological Chemistry, vol. 277, pp. 37340-37438.
“siRNA Target Finder.” results for the entry of the nucleotide sequence of GeneBank Accession No. NM—021960. http://www.ambion.com/techlib/misc/siRNA—finder.html, accessed on Mar. 6, 2008 in U.S. Appl. No. 11/633,404.
Futami, et al. (2002) Induction of Apoptosis in Hela Cells with siRNA Expression Vector Targeted Against BCL-2. Nucleic Acids Research Supplement No. 2:251-252.
Promega (2003) siRNA Target Designer-Version 1.1, SilentGene U6 Cassette RNA Interference System. http:///www.promega.com/siRNADesigner/program.
Marathi et al. RAD1, A Human Structural Homolog of the Schizosaccharomyces pombe RAD1 Cell Cycle Checkpoint Gene, 1998, Genomics, vol. 54, pp. 344-347.
Kalra, et al., Central Administration of Antisense oligodeoxynucleotides to neuropeptide Y (NPY) mRNA reveals the critical role of newly synthesized NPY in regulation of LHRH release, 1995, Regulatory Peptides, vol. 59, pp. 215-220.
Boutla et al., Short 5′-phosporylated double-stranded RNAs induce RNA interference inDrosophila, 2001, Current Biology, vol. 11, pp. 1776-1780.
NCBI Sequence Viewer v2.0 for NM-000905, http://www.ncbi.nlm.nih.gov/entrez/viewer, accessed on Mar. 18, 2008.
siRNA Converter, http://web.archive.org/web/20020101-20021231re—/http://www.ambion.com/techlib/misc/siRNA—finder.html.
siRNA Design for RNA Interference (RNAi) Experiments, http://web.archive.org/ web/20010101000000-20021231235959/http://www.ambion.com/techlib/misc/siRNA—design.html.
Reynolds, et al., Rational siRNA design for RNA interference, Nature Biotechnology, Mar. 2004, vol. 22, No. 3, pp. 326-330.
Ui-Tei, et al., Guidelines for the selection of highly effective siRNA sequences for mammalian and chick RNA interference, Nucleic Acids Research, Feb. 2004, vol. 32, No. 3, pp. 936-948.
Tusterman, et al., Dicers at RISC: The Mechanism of RNAi, Cell, Apr. 2004, vol. 117, pp. 1-4.
Brusca, John S., PCT International Search Report, United States Patent and Trademark Office, Sep. 24, 2007.
Epps-Ford, Janet L., PCT International Search Report, United States Patent and Trademark Office, Feb. 25, 2005.
Kasif, et al., A Computational Framework for Optimal Masking in the Synthesis of Oligonucleotide Microarrays, Nucleic Acids Research, 2002, vol. 30, No. 20, pp. 1-6.
Khvorova, et al., Functional siRNAs and miRNAs Exhibit Strand Bias, Cell, Oct. 2003, vol. 115, pp. 209-216.
Amarzguioui, et al., Secondary Structure Prediction and in vitro Accessibility of mRNA as Tools in the Selection of Target Sites for Ribozymes, Nucleic Acids Research, 2000, vol. 28, No. 21, pp. 4113-4124.
Elbashir, et al., Analysis of Gene Function in Somatic mammalian Cells using small Interfering RNAs, Methods, 2000, vol. 26, pp. 199-213.
Elabashir, et al., Functional Anatomy of siRNAs for Mediating Efficient RNAi inDrosophila melanogasterembryo lysate, European Molecular Biology Organization, 2001, pp. 6877-6888.
Abifadel et al., Mutations in PCSK9 cause autosomal dominant hypercholesterolemia, 2003, Nature Genetics, vol. 34, pp. 154-156.
Ishibashi et al., A Novel Dual Specificity Phosphatase Induced by Setum Stimulation and Heat Shock, (1994) J. Biol. Chem. 47: 29897-2902).
Rashid et al. Decreased plasma cholesterol and hypersensitivity to statins inmice lacking PCSK9, 2005 PNAS, vol. 102, pp. 5374-5379.
siDesign Center for “gene name: src,” http://www.dharmacon.com/DesignCenter/DesignCenterPage.aspx, accessed on May 13, 2008.
siRNA Design for RNA Interference (RNAi) Experiments, http://web.archive.org/ web/20010101000000-20021231235959/http://www.ambion.com/techlib/misc/siRNA—design.html. Accessed on Mar. 6, 2008.
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