Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2009-01-22
2010-10-19
Landsman, Robert (Department: 1646)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C530S350000
Reexamination Certificate
active
07816091
ABSTRACT:
The present invention relates to a novel human gene encoding a polypeptide which is a member of the Cytokine Receptor family. More specifically, the present invention relates to a polynucleotide encoding a novel human polypeptide named Cytokine Receptor Common Gamma Chain Like, or “CRCGCL.” This invention also relates to CRCGCL polypeptides, as well as vectors, host cells, antibodies directed to CRCGCL polypeptides, and the recombinant methods for producing the same. Also provided are diagnostic methods for detecting disorders related to the immune system, and therapeutic methods for treating diagnosing, detecting, and/or preventing such disorders. The invention further relates to screening methods for identifying agonists and antagonists of CRCGCL activity.
REFERENCES:
patent: 6844170 (2005-01-01), Moore et al.
patent: 6861227 (2005-03-01), Ruben et al.
patent: 6955895 (2005-10-01), Pandey et al.
patent: 6982320 (2006-01-01), Moore et al.
patent: 2002/0068323 (2002-06-01), Saris et al.
patent: 2003/0186875 (2003-10-01), De Waal Malefyt et al.
Wells, Biochemistry 29:8509-8517, 1990.
Carping, et al. “Absence of an Essential Role for Thymic Stromal Lymphopoietin Receptor in Murine B-Cell Development.” Molecular and Cellular Biology, Mar. 2004, pp. 2584-2592.
Leonard, “TSLP Is Now Revealed to Be an Important Regulator of DEC-Mediated Control of TH2-Based Human Allergic Responses, Identifying a Potentially New Species-Specific Function for This Cytokine.” Nature Immunology, vol. 3, No. 7, Jul. 2002, pp. 605-607.
Liu, “Thymic Stromal Lymphopoietin: Master Switch for Allergic Inflammation.” JEM, vol. 203, No. 2, Feb. 20, 2006, pp. 269-273.
Ziegler, et al. “Thymic Stromal Lymphopoietin in Normal and Pathogenic T Cell Development and Function.” Nature Immunology, vol. 7, No. 7, Jul. 2006, pp. 709-714.
Corrigan, et al. “Early Production of Thymic Stromal Lymphopoietin Precedes Infiltration of Dendritic Cells Expressing Its Receptor in Allergen-Induced Late Phase Cutaneous Responses In Atopic Subjects.” Allergy, in Press.
Yoo et al. Database EMBL [Online] EMBL; Cytokine Receptor Common Gamma; Nov. 1, 1997; Database accession No. Q95118.
Vincenti, et al. “Interleukin-2-Receptor Blockade with Daclizumab to Prevent Acute Rejection in Real Transplantation.” New England Journal of Medicine, vol. 338, No. 3, Jan. 15, 1998, pp. 161-165.
European Search Report dated Sep. 16, 2008 issued in European Patent Application No. 08006530.3.
Al-Shami, A., et al., “A role for TSLP in the development of inflammation in an asthma model,” JEM 202(6):829-839 (Sep. 2005).
Bocchino, V ., et al., “Short-term Treatment with a Low Dose of Inhaled Fluticasone Propionate Decreases the Number of CD1 a+ Dendritic Cells in Asthmatic Airways,” Pulm Pharmacol Ther. 10(5-6):253-9 (1997).
Boguniewicz, M., “Advances in the understanding and treatment of atopic dermatitis,” Curr Opin Pediatr. 9 (6):577-81(Dec. 1997).
Cooper, K.D., “Atopic Dermatitis: Recent Trends in Pathogenesis and Therapy,” J Invest Dermatol 102(1):128-37 (Jan. 1994).
Friend, S.L., et al., “A thymic stromal cell line supports in vitro development of surface IgM+ B cells and produces a novel growth factor affecting B and T lineage cells,” Experimental Hematology 22:321-328 (1994).
Hallstrand, T.S., et al., “Peripheral blood manifestations of TH2 lymphocyte activation in stable atopic asthma and during exercise-induced bronchospasm,” Ann Allergy Asthma Immunol 80(5):424-32 (May 1998).
Hsu, C.H., et al., “Glutathione-S-transferase induces murine dermatitis that resembles human atopic dermatitis,” Clin Exp Allergy 26(11):1329-37 (1996).
Ihle, J.N. and Kerr, I.M., “Jaks and Stats in signaling by the cytokine receptor superfamily,” Trends Genet. 11 (2):69-74 (1995).
Isaksen, D.E., et al., “Requirment for Stat5 in Thymic Stromal Lymphopoietin-Mediated Signal Transduction,” The Journal of Immunology 163:5971-5977 (1999).
Keane-Myers, A., et al., “Resistance to Antigen-Induced Airway Hyperresponsiveness Requires Endogenous Production of IL-12,” The Journal of Immunology 161:919-926 (1998).
Levin, S.D., et al. “Thymic Stromal Lymphopoietin: A Cytokine That Promotes the Development of IgM+ B Cells In Vitro and Signals Via a Novel Mechanism,” The Journal of Immunology 162:677-683 (1999).
Murray, K.M. and Dahl, S.L., “Recombinant Human Tumor Necrosis Factor Receptor (p75) Fc Fusion Protein (TNFR:Fc) in Rheumatoid Arthritis,” Ann Pharmacother 31(11):1335-8 (Nov. 1997).
Özsahin, H., et al., “Blockade of Acute Grade IV Skin and Eye Graft-Versus-Host Disease by Anti-Interleukin-2 Receptor Monoclonal Antibody in Genoidentical Bone Marrow Transplantation Setting,” Turk J Pediatr. 40(2):231-5 (Apr.-Jun. 1998).
Pandey, A., et al., “Cloning of a receptor subunit required for signaling by thymic stromal lymphopoietin,” Nature Immunology 1:59-64 (Jul. 2000).
Park, L.S., et al., “Cloning of the Murine Thymic Stromal Lymphopoietin (TSLP) Receptor: Formation of a functional Heteromeric Complex Requires Interleukin 7 Receptor,” The Journal of Experimental Medicine 192(5):659-669 (Sep. 2000).
Patterson, R. and Harris, K., “Chronic Pruritic Dermatitis in Asthmatic Monkeys: A Subhuman Primate Analogue of Atopic Dermatitis?” Int Arch Allergy Immunol 64(3):332-7 (1981).
Pauwels, R.A., et al., “Cytokine Manipulation in Animal Models of Asthma,” Am J Respir Crit Care Med 156:S78-S81 (1997).
Plum, J., et al., “Interleukin-7 Is a Critical Growth Factor in Early Human T-Cell Development,” Blood 88 (11):4239-4245 (Dec. 1996).
Quentmeier, H., et al., “Cloning of human thymic stromal lymphopoietin (TSLP) and signaling mechanisms leading to proliferation,” Leukemia 15:1286-1292 (2001).
Rochman, I., et al., “Cutting Edge: Direct Action of Thymic Stromal Lymphopoietin on Activated Human CD4+ T Cells,” The Journal of Immunology 178:6720-6724 (2007).
Sims, J.E., et al., “Molecular Cloning and Biological Characterization of a Novel Murine Lymphoid Growth Factor,” The Journal of Experimental Medicine 192(5):671-680 (Sep. 2000).
Spergel, J.M., et al., “Epicutaneous Sensitization with Protein Antigen Induces Localized Allergic Dermatitis and Hyperresponsiveness to Methacholine after Single Exposure to Aerosolized Antigen in Mice,” J. Clin. Invest. 101 (8):1614-1622 (Apr. 1998).
Sudo, T., et al., “Expression and function of the interleukin 7 receptor in murine lymphocytes,” Proc. Natl. Acad. Sci. USA 90:9125-9129 (Oct. 1993).
Takizawa, H., “Airway epithelial cells as regulators of airway inflammation (Review),” Int J Mol Med 1(2):367-78 (Feb. 1998).
Thiel, S., et at., “Internalization of the interleukin 6 signal transducer gp 130 does not require activation of the Jak/STAT pathway,” Biochem. J. 330:47-54 (Feb. 1998).
Declaration of Interference No. 105,613 (Jan. 28, 2008).
Human Genome Sciences Opposition 2 with attached Exhibits.
Portolana et al. “Lack of Promiscuity in Autoantigen-Specific H and L Chain Combinations as Revealed by Human H and L Chain ‘Roulette.’” J. Immunology, vol. 50, No. 3, Feb. 1, 1993, pp. 880-887.
Queen et al. “A Humanized Antibody That Binds to the Interleukin 2 Receptor.” Proc. Natl. Acad. Sci. USA, vol. 86, Dec. 1989, pp. 10029-10033.
Leonard, W., “TSLP: finally in the limelight,” Nature Immunology, 3(7):605-607 (Jul. 2002).
Liu, Y-J., “Thymic stromal lymphopoietin: master switch for allergic inflammation,” The Journal of Experimental Medicine, 203(2):269-273 (Feb. 20, 2006).
Yoo, J. et al., “Spontaneous atopic dermatitis in mice expressing an inducible thymic stromal lymphopoietin transgene specifically in the skin,” The Journal of Experimental Med
Moore Paul A.
Rosen Craig A.
Ruben Steven M.
Chandra Gyan
Human Genome Sciences Inc.
Kenyon & Kenyon LLP
Landsman Robert
LandOfFree
Method of identifying a binding partner to a cytokine... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method of identifying a binding partner to a cytokine..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of identifying a binding partner to a cytokine... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4217981