Fibroblast growth factor homologous factor-2 and methods of use

Details Fibroblast growth factor homologous factor-2 and methods of use Fibroblast growth factor homologous factor-2 and methods of use

1995-05-12

1999-03-02

Kemmerer, Elizabeth C.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435 691, 435 902, 4352523, 4353201, 536 235, 536 2351, 935 23, 935 69, 935 70, 935 71, 935 72, C12N 1500, C12N 1563, C12N 1582, C07H 2104

Patent

active

058769676

ABSTRACT:
A novel growth factor, fibroblast growth factor homologous factor-2 (FHF-2) polypeptide, the polynucleotide sequence encoding FHF-2 and the deduced amino acid sequence are disclosed. Also disclosed are diagnostic and therapeutic methods of using the FHF-2 polypeptide and polynucleotide sequences and antibodies which specifically bind to FHF-2.

REFERENCES:
Adams M D; Soares M B; Kerlavage A R; Fields C; Venter J C. Rapid cDNA sequencing (expressed sequence tags) from a directionally cloned human infant brain cDNA library. Nature Genetics, (1993 Aug.) 4 (4) 373-80.
Molecular Cloning A Laboratory Manual. Second Edition vols. 1 2 and 3. Sambrook J; Fritsch E F; Maniatis T. Cold Spring Harbor Laboratory Press; Cold Spring Harbor, New York, USA, Chapter 11, p. 47, Nov. 1989.
Methods in Enzymology, vol. 152, Guide to Molecular Cloning Techniques. Berger et al, ed. Academic Press, New York, NY. 1987, Chapter 47, pp. 432-443, Jun. 1988.
Journal of Cellular Physiology, vol. 162 No. 3 Mar 1995 Quantitative Export of F6F-2 occurs Through an Alternative, Energy-Dependent, Non-ER/Golgi Pathway, pp. 388-399.
Development vol. 118 1993 pp. 95-104 Retroviral expression of F6F-2 (6FGF) affects patterning in chick limb bud.
Febs letters, vol. 349 3 Jun. 1994, Purification and Characterization of 210-amino acid recombinant basic fibroblast growth factor form (F6F-2).
Cell Growth and Differentiation, vol. 2 No. 11 Nov. 1991, Production and Functional Characterization of Human Recombinant F6F-6 Protein.

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