Reduction of the hook effect in assay devices

Details Reduction of the hook effect in assay devices Reduction of the hook effect in assay devices

2003-04-03

2010-12-14

Yang, N C (Department: 1641)

Chemistry: molecular biology and microbiology

Apparatus

Including measuring or testing

C435S286500, C435S287700, C436S528000, C436S533000, C436S535000, C427S002110, C427S002130

Reexamination Certificate

active

07851209

ABSTRACT:
A membrane-based assay device for detecting the presence or quantity of an analyte residing in a test sample is provided. The device utilizes conjugated probes that contain a specific binding member for the analyte of interest. The specific binding member preferentially complexes with the analyte within a test sample when contacted therewith. Excess analyte that remains uncomplexed with the specific binding member undergoes non-specific binding, such as to a hydrophobic domain. As a result, the ability of the uncomplexed analyte to compete with the complexed analyte at the detection zone of the device is restricted. Thus, the incidence of “false negatives” is limited in a simple, efficient, and relatively inexpensive manner.

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