Chemistry: molecular biology and microbiology – Virus or bacteriophage – except for viral vector or...
Reexamination Certificate
2005-02-21
2010-02-09
Lucas, Zachariah (Department: 1648)
Chemistry: molecular biology and microbiology
Virus or bacteriophage, except for viral vector or...
C435S069100, C435S239000, C435S320100, C536S023720, C424S228100, C424S093100, C424S093200, C424S093600
Reexamination Certificate
active
07659103
ABSTRACT:
The present invention provides a method for replicating efficiently an RNA containing fulllength HCV genomic sequence and a method for producing HCV virus particles containing fulllength HCV replicon RNA or fulllength HCV genomic RNA by using a cell culture system. Further, the present invention relates to a method for producing hepatitis C virus particles which comprises culturing a cell, into which a replicon RNA comprising a nucleotide sequence comprising a fulllength genomic RNA sequence of hepatitis C virus of the genotype 2a, at least one selectable marker gene and/or at least one reporter gene and at least one IRES sequence or the fulllength genomic RNA of hepatitis C virus of the genotype 2ais introduced, and generating virus particles in the culture medium. Still further the present invention relates also to a hepatitis C vaccine and an antibody against hepatitis C virus particles.
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Date Tomoko
Kato Takanobu
Miyamoto Michiko
Sone Saburo
Tanabe Jun-ichi
Birch & Stewart Kolasch & Birch, LLP
Lucas Zachariah
Tokyo Metropolitan Organization For Medical Research
Toray Industries Inc.
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