Chemistry: molecular biology and microbiology – Maintaining blood or sperm in a physiologically active state...
Reexamination Certificate
2007-06-28
2010-12-14
Saucier, Sandra (Department: 1651)
Chemistry: molecular biology and microbiology
Maintaining blood or sperm in a physiologically active state...
Reexamination Certificate
active
07851142
ABSTRACT:
Cell membrane maintenance of red blood cells and platelet concentrates is improved by the addition of 1 mM-10 mM L-carnitine and derivatives. This improvement allows extension of the period of viability of packed red blood cells and platelet concentrations beyond current periods. Additionally, the materials so treated exhibit extended circulation half life upon transfusion to a patient. Improvements in membrane maintenance achieved by this method permit irradiation of sealed containers of blood products so as to substantially sterilize and destroy leukocytes in the same.
REFERENCES:
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patent: 6403124 (2002-06-01), Dottori
patent: 6482585 (2002-11-01), Dottori
patent: 6960428 (2005-11-01), Dottori
Sweeney, et al., “L-Carnitine and L-Acetylcarnitine May Reduce Glycolysis in Stored Platelet Concentrates”, Vox Sanguinis, (Jun. 1998), 74, (1): 1226, 25th Congress of the International Society of Blood Transfusion, Oslo, Norway, Jun. 27-Jul. 2, 1998.
A. Arduini, et al., Addition of L-Carnitine to Additive Solution-Suspended Red Cells Stored at 4 Degrees Reduces In Vitro Hemolysis and Improves In Vivo Viability, Transfusion, Feb. 1997, 37 (2), pp. 166-174 (Abstract Only).
Arduini Arduino
Dottori Secondo
Lucas & Mercanti LLP
Saucier Sandra
Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
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