Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2008-03-28
2010-11-23
Calamita, Heather G (Department: 1637)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C435S091100, C435S091200, C536S024330, C536S023100, C536S022100
Reexamination Certificate
active
07838235
ABSTRACT:
Provided herein are methods for assaying a biological sample for microorganisms having drug resistant and/or drug sensitive phenotypes, wherein the methods are capable of detecting resistant and sensitive phenotypes associated with known and/or unknown mutations. In some aspects, methods are provided for detecting drug resistantMyobacterium tuberculosis(MTb), including multi-drug resistant MTb, wherein drug resistance is associated with one or more novel mutations. Also provided are systems, kits, and compositions related to such methods.
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Torres, M.J. et al., “Improved Real-Time PCR for Rapid Detection of Rifampin and Isoniazid Resistance inMycobacterium TuberculosisClinical Isolates,” Diagnostic Microbiology and Infectious Disease, 2003, pp. 207-212, vol. 45.
Calamita Heather G
Fenwick & West LLP
Signal Diagnostics
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