Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or...
Reexamination Certificate
2005-04-14
2010-06-22
Cochrane Carlson, Karen (Department: 1657)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Reexamination Certificate
active
07741020
ABSTRACT:
This invention relates to methods for determining the activity of Lp-PLA2 in at least one sample from an animal. The invention also relates to methods for determining the inhibition of Lp-PLA2 activity in samples from animals that are administered an Lp-PLA2 inhibitor.
REFERENCES:
patent: 2003/0148398 (2003-08-01), McPhee et al.
patent: 2007/0166777 (2007-07-01), Shou et al.
patent: 816504 (1998-01-01), None
patent: 1318154 (2003-06-01), None
patent: 05779946.2-2401 (2007-07-01), None
patent: 06116279 (1994-04-01), None
patent: 07059597 (1995-03-01), None
patent: 2002-179545 (2002-06-01), None
patent: WO 9509921 (1995-04-01), None
patent: WO 0032808 (2000-06-01), None
patent: WO2004089184 (2004-10-01), None
patent: WO2005/001416 (2005-01-01), None
patent: 2005/074604 (2005-08-01), None
patent: WO 2005/074604 (2005-08-01), None
Thirkettle et al. (Jul. 2000) J. Antibiotics 53, 664-669.
Thirkettle (Jul. 2000) J. Antibiotics 53, 733-735.
Boyd et al. [A] (Feb. 21, 2000) Bioorg Med Chem Lett 10, 395-398.
Boyd et al. [B] (Dec. 4, 2000) Bioorg Med Chem Lett 10, 2557-2561.
Tew et al. (Jun. 24, 1998) Biochem 37, 10087-10093.
Tew et al. (Apr. 1996) Arteriosclerosis, Thrombosis Vasc Biol. 16(4), 591-599.
Thirkettle et al. J Antibiotics 2000;53(7):664-669.
Kosaka T, et al., “Spectrophotometric Assay for Serum Platelet-Activating Factor Acetylhydrolase Activity,”Clinica Chimica Acta(2000) 296(1-2):151-161.
Kosaka T, et al., “Serum Platelet-Activating Factor Acetylhydrolasse (PAFAH) Activity in more than 3000 Healthy Japanese,”Clinica Chimica Acta(2001)313(1-2):179-183.
Koenig W, et al., “Lipoprotein-Associated Phospholipase A2Adds to Risk Prediction of Incident Coronary Events by C-Reactive Protein in Apparently Healthy Middle-Aged Men from the General Population”Circulation(Oct. 2004) 110(14):1903-1908.
Balafa O, et al., “Urine of Patients with Nephritic Syndrome Contains the Plasma Type of PAF-Acetylhydrolase Associated with Lipoproteins,”Nephron Physiology(2004)97(3):45-52.
Sarchielli P, et al., “Platelet-Activating Factor (PAF) in Internal Jugular Venous Blood of Migraine without Aura Patients Assessed During Migraine Attacks,”Cephalagia(2004) 24(8):623-630.
Karkabounas A., et al., “Quantitative Fluorescence Determination of Phospholipase A2and PAF Acetylhydrolase in Biological Fluids using High Performance Liquid Chromatography,”Chemistry and Physics of Lipids(Jun. 2004)130(1):69-70.
Brites F, et al., “Paraoxonase 1 and Platelet-Activating Factor Acetylhydrolase Activities in Patients with Low HDL-Cholesterol Levels with or without Primary Hypertriglyceridemia,”Archives of Medical Research(May 2004)35(3):235-240.
Kujiraoka T, et al., “Altered Distribution of Plasma PAF-AH between HDLs and other Lipoproteins in Hyperlipidemia and Diabetes Mellitus,”Journal of Lipid Research(Oct. 2003) 44(10):2006-14.
Ito T, et al., “Serum PAF-Acetylhydrolase (PAF-AH) in Hepatobiliary Disease,”Japanese Pharmacology and Therapeutics(2002) 30/Suppl. 2.
Unno, N et al., “Single Nucleotide Polymorphism (G994→T) in the Plasma Platelet-Activating Factor-Acetylhydrolase Gene is Associated with Graft Patency of Femoropopliteal Bypass,”Surgery(2002) 132(1):66-71.
Dada, N, et al, “LP-PLA2: an emerging biomarker of coronary heart disease,”Expert Review of Molecular Diagnostics(Jan. 2002) 2(1):17-22.
Ibe B, et al. “Platelet Activating Factor Acetylhydrolase Activity in Lamb Lungs is Up-Regulated in the Immediate Newborn Period,”Molecular Genetics and Metabolism(Jan. 2000) 69(1):46-55.
Deigner H, et al., “Novel reversible, irreversible and fluorescent inhibitors of platelet-activating factor acetylhydrolase as mechanistic probes,”Atherosclerosis(May 1999) 144(1):79-90.
Kitsiouli E, et al. “Differential Determination of Phospholipase A(2) ane PAF-Acetylhydrolase in Biological Fluids Using Fluorescent Substrates,”Journal of Lipid Research(Dec. 1999) 40(12):2346-2356.
Hendrickson HS, et al., “Intramolecularly Quenched BODIPY-Labeled Phospholipids Analogs in Phospholipase A2and Platelet-Activating Factor Acetylhydrolase assays and in Vivo Fluorescence Imaging,”Analytical Biochemistry(Dec. 1999) 276(1):27-35.
Akiyama M, et al., “Identification of a Major PAF Acetylhydrolase in Human Serus/Plasma as a 43 KDa Glycoprotein Containing about 9 kDa Asparagine-Conjugated Sugar Chain(s),”Journal of Biochemistry(May 1998) 123(5):786-789.
Servillo L, et al., “Simultaneous Determination of Lysophospholipids by High-performance Liquid Chromatography with Fluorescence Detection,”Journal of Chromatography(1997) 689(B):281-286.
Patrick DA, et al., “Reduced PAF-Acetylhydrolase Activity is Associated with Postinjury Multiple Organ Failure,”,Shock(Mar. 1997)7(3):170-174.
Tsukioka K, et al., “Increased Plasma Level of Platelet-Activating Factor (PAF) and Decreased Serum PAF Acetylhydrolase (PAFAH) Activity in Adults with Bronchial Asthma,”Journal of Investigational Allergology and Clinical Immunology(1996)6(1):22-29.
Balestrieri C, et al., “Measurement of Platelet-Activating Factor Acetylhydrolase Activity by Quantitative High-Performance Liquid Chromatography Determination of Courmarin-Derivatized 1-0-alkyl-2-sn-lysoglyceryl-3-phosphorylcholine,”Analytical Biochemistry(Jan. 1996)233(2):145-50.
Riehl TE and Stenson WF., “Platelet-activating factor acetylhydrolases in Caco-2 cells and epithelium of normal and ulcerative colitis patients,”Gastroenterology(1995)109(6):1826-1834.
Masaki A, et al., “New Serum PAF acetylhydrolase detection method used with the Blotting Method and Beta of3Hacetyl-PAF,”Proceedings of Japanese Conference on the Biochemistry of Lipids(1994)36:43-46.
Hemmings R, et al., “Platelet-Activating Factor Acetylhydrolase Activity in Peritoneal Fluids of Women with Endometriosis,”Obstetrics and Gynecology(Feb. 1993)81(2):276-279.
Masao M et al., “On Development of a Measurement Method of Serum PAF Acetylhydrolase Activity Using an Automatic Analyser, and the Clinical Significance of Serum PAF Acetylhydrolase Defect,”Proceedings of Japanese Conference on the Biochemistry of Lipids(1992)34:305-308.
Stafforini D., et al., “Platelet-Activating Factor Acetylhyrolase in Human erythrocytes,”Methods in Enzymology(1991)197:411-425.
Kirschbaum B, “Platelet Activating Factor Acetylhydrolase activity in the urine of patients with renal disease,”Clinical Chimica Acta(Jun. 14, 1991)199(2):139-146.
Imaizumi T et al., “Activity of platelet-activating factor (PAF) acetylhydrolase in plasma from healthy habitual cigarette smokers”Heart and Vessels(1990)5(2):81-86.
Matsuzaki Masaharu, “Measurement Methods of Platelet Activating Factor (PAF) and PAF Acetylhydrolase (PAFAH) Activity,”SRL Hokan(1989)13(3): 36-41.
Schindler PW, et al, “Fluorophore-labeled ether lipids: substrates for enzymes of the platelet-activating factor cycle in peritoneal polymorphonuclear leukocytes,”Analytical Biochemistry(Nov. 1988) 174(2):477-84.
Miyake MM, et al, “Characterization of serum platelet-activating factor (PAF) acetylhydrolase. Correlation between deficiency of serum PAF acetylhydrolase and respiratory symptoms in asthmatic children.”Journal of Clinical Investigation(Dec. 1988)82(6):1983-1991.
Masao Miwa, et al., “Serum platelet-activating factor (PAF) acetylhydrolase of children with bronchial asthma,”Japanese Journal of Inflammation(1988)8(4):327-333.
Satoh Kei, et al, “Platelet-activating factor (PAF) acetylhydrolase and plasma lipoproteins: Relative distribution of the activity among lipoprotein classes,”Journal of Japan Atheroschlerosis Society(1988)16(4):501-504.
Stafforini D, et al., “Human Plasma Platelet-Activating Factor Acetylhyrolase. Purification and Properties,”Journal of Biological Chem
Shou Yaping
Siu Yin-Fai
Walker George T.
Carlson Karen Cochrane
Gimmi Edward R.
Glaxo Group Limited
Kanagy James M.
Kinzig Charles M.
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