Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2006-10-10
2010-11-02
Schnizer, Richard (Department: 1635)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C536S024500
Reexamination Certificate
active
07825230
ABSTRACT:
The present invention relates to human microRNA targets in HIV genome and a method of identification thereof. Using multiple software targets to six human microRNAs [miRNAs] were discovered in the net, vpr, env, and I vif genes. The miRNAs were identified as hsa-miR-29a, hsa-miR-29b, hsa-miR-29c, hsa-mir-149, hsa-mir-324-5p, hsa-mir-378. These miRNAs or its homologues can be used as therapeutics against HIV infection. The invention further relates to a novel strategy to target genes of HIV-1 by human microRNAs, or its homologues, to inactivate or block HIV activity. The computational approach towards identification of human miRNA targets in the HIV genome and the variation in the microRNA levels was further validated experimentally.
REFERENCES:
patent: 5474796 (1995-12-01), Brennan
Lagos-Quintana et al (Science 294: 853-858, 2001).
Dostie et al (RNA 9(2): 180-186, 2003).
Ratner et al (Nature 313(6000): 277-284, 1985).
Gen Bank K03455 (2002).
Buck et al (Biotechniques 27: 528-536, 1999).
Svanholm et al (Scand. J. Immunol. 46: 298-303, 1997).
GenBank Accession AF324493, 2001.
Brahmachari Samir Kumar
Hariharan Manoj
Pillai Beena
Scaria Vinod
Council of Scientific & Industrial Research
Harness Dickey & Pierce PLC
Schnizer Richard
LandOfFree
Human microRNA targets in HIV genome and a method of... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Human microRNA targets in HIV genome and a method of..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Human microRNA targets in HIV genome and a method of... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4184272