Mutant forms of meningococcal ADP-ribosylating toxin

Details Mutant forms of meningococcal ADP-ribosylating toxin Mutant forms of meningococcal ADP-ribosylating toxin

2003-09-01

2010-12-28

Raghu, Ganapathirama (Department: 1652)

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Amino acid sequence disclosed in whole or in part; or...

C424S184100, C435S199000, C536S023200, C530S300000, C530S328000, C530S329000, C530S350000

Reexamination Certificate

active

07858096

ABSTRACT:
NMB1343 is an ADP-ribosylating toxin fromNeisseria meningitidis. The invention provides a mutant toxin having a substitution at one or more of amino Glu-109, Glu-111 or Glu-120. The mutations(s) is/are preferably Glu to Asp. The protein of the invention preferably has reduced or eliminated ADP-ribosyltransferase and/or NAD-glycohydrolase activity relative to the wild-type protein.

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