Napthoquinone antibiotics from fuserium solani

Details Napthoquinone antibiotics from fuserium solani Napthoquinone antibiotics from fuserium solani

1988-05-10

1989-06-06

Lilling, Herbert J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514682, 435126, 435156, 435170, 435929, C12P 102, C12P 726

Patent

active

048373990

ABSTRACT:
Three naphthoquinones isolated from cultures of Fusarium solani were found to be effective antibiotics against gram-positive bacteria. Controlling the dissolved oxygen concentration in the fermentation medium between 0.7 and 2.0 ppm resulted in maximum yields of the naphthoquinones. 2,3-Dihydro-5,8-dihydroxy-6-methoxy-2-hydroxymethyl-3-(2-hydroxypropyl)-1, 4- naphtholenedione was the most effective antibiotic.

REFERENCES:
patent: 3959468 (1976-05-01), Burmeister
patent: 4238405 (1980-12-01), Felix
H. Kern, "The Naphthazarins of Fusarium", Ann. Phytopathol. 10: 327-345 (1978).
J. H. Tatum et al., "Three Further Naphthoquinones Produced by Fusarium Solani", Phytochemistry 24: 3019-3021 (1985).
T. W. Flegel et al., "A New Naphthoquinone Antibiotic From a New Species of Yeast", J. Antibiot. 37: 325-329 (1984); Chem. Abst. 101: 267 (1984).
V. P. Papageorgiou et al., "Study on the Antibiotic Fraction of Alkanna Tinctoria Tausch", Chem. Chron. 9: 57-63 (1980); Chem. Abst. 94: 120 (1981).

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