Inhibitors of fatty acid amide hydrolase

Details Inhibitors of fatty acid amide hydrolase Inhibitors of fatty acid amide hydrolase

2003-10-08

2010-02-16

Seaman, D. Margaret (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

active

07662971

ABSTRACT:
Improved competitive inhibitors of FAAH employ an α-keto heterocyclic pharmacophore and a binding subunit having a ?-unsaturation. The α-keto heterocyclic pharmacophore and a binding subunit are attached to one another, preferably by a hydrocarbon chain. The improvement lies in the use of a heterocyclic pharmacophore selected from oxazoles, oxadiazoles, thiazoles, and thiadiazoles that have alkyl or aryl substituents at their 4 and/or 5 positions. The improved competitive inhibitors of FAAH display enhanced activity over conventional competitive inhibitors of FAAH.

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Chemical Abstracts Online, Registry No. 76115-66-7, © 2009 ACS on STN, 1 pg.
“International Application Serial No. PCT/US03/31975, International Search Report mailed Jul. 30, 2004”, 1 pg.

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