Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Reexamination Certificate
2004-05-18
2010-11-09
Swartz, Rodney P. (Department: 1645)
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
C424S009100, C424S009200, C424S184100, C424S185100, C424S190100, C424S200100, C424S234100, C424S278100, C530S300000, C530S350000
Reexamination Certificate
active
07829103
ABSTRACT:
The invention concerns a methylated immunogenic recombinant peptide sequence comprising mycobacterial heparin-binding hemagglutinin. The invention also concerns chemical and enzymatic methods for preparing such a sequence, the sequence being previously produced in a non-methylated recombinant form then methylated by post-translational modification. The invention further concerns recombinant tools, vectors and host cells for implementing post-translational enzymatic methylation of the recombinant HBHA. The invention finally concerns immunogenic compositions comprising methylated, native or recombinant HBHA, such compositions being useful for preparing vaccines against mycobacterial infections.
REFERENCES:
patent: 5717064 (1998-02-01), Julian et al.
patent: WO 97/44463 (1997-11-01), None
Menozzi, F.D., et al. “Identification of a Heparin-binding Hemagglutinin Present in Mycobacteria”, J. Exp. Med., vol. 184, pp. 993-1001, Sep. 1996.
F. D. Menozzi et al., Proc Natl Acad Sci USA, Oct. 13, 1998, 95(21):12625-12630.
Pethe et al: “Mycobacterial heparin-binding hemagglutinin and laminin-binding protein share antigenic methyllysines that confer resistance to proteolysis” Proceedings of the National Academy of Sciences, USA, vol. 99, Aug. 6, 2002, pp. 10759-10764.
Pethe et al: “Functional and immunological characterizations of the lysine-rich repeats in the C-terminal domain of the mycobacterial heparin-binding hemagglutinin” Abstracts of the General Meeting of the American Society for Microbiology, The Society, Washington, DC, US, vol. 99, No. 231/U-106, May 30, 1995, p. 654.
Poncz et al: “The resistance to tryptic hydrolysis of peptide bonds and adjacent to Ne, N-dimethyllysyl residues” Journal of Biological Chemistry, vol. 258, Feb. 10, 1983, pp. 1844-1850.
Pethe et al: “Characterization of the heparin-binding site of the mycobacterial heparin-binding hemagglutinin adhesin” Journal of Biological Chemistry, vol. 275, May 12, 2000, pp. 14273-14280.
Joys et al: “The susceptibility to tryptic hydrolysis of peptide bonds involving epsilon-N-methyllysine” Biochimica et Biophysica Acta, No. 581, 1979, pp. 360-362.
Locht Camille
Menozzi Franco
Pethe Kevin
Birch Stewart Kolasch & Birch, LLP.
Institut National de la Sante Et de la Rechereche Medicale
Institut Pasteur de Lille
Swartz Rodney P.
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