Transgenic nonhuman mammal representing the pathologic...

Details Transgenic nonhuman mammal representing the pathologic... Transgenic nonhuman mammal representing the pathologic...

2005-03-08

2010-06-29

Long, Scott (Department: 1633)

Multicellular living organisms and unmodified parts thereof and

Nonhuman animal

Transgenic nonhuman animal

C800S008000, C800S009000, C800S013000, C800S014000

Reexamination Certificate

active

07745690

ABSTRACT:
It is intended to provide a transgenic nonhuman mammal well representing the pathologic conditions of human rheumatoid arthritis. A transgenic nonhuman mammal is obtained by transferring a foreign DNA, wherein a DNA selected from the group consisting of an MHC class II transcriptional activator gene, the activity domain of an MHC class II transcriptional activator gene and a variant of an MHC class II transcriptional activator gene is provided under the control of a type II collagen promoter, into a cell at the early stage of development.

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