Methods for screening agents that modulate presenilin...

Chemistry: analytical and immunological testing – Biospecific ligand binding assay

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C435S007100, C435S007800

Reexamination Certificate

active

07851228

ABSTRACT:
The disclosure relates generally to neurodegenerative disorders and more specifically to a group of presenilin/G-protein/c-src binding polypeptides and methods of use for modulating signaling and progression of Alzheimer's disease.

REFERENCES:
patent: 2002/0015939 (2002-02-01), McCarthy
patent: 2002/0016978 (2002-02-01), Zheng
patent: 2002/0064828 (2002-05-01), Monteiro
patent: 2002/0082211 (2002-06-01), Arvizu
patent: 2002/0086444 (2002-07-01), Tanzi
patent: 2003/0059938 (2003-03-01), Annaert
patent: 2003/0065141 (2003-04-01), Carter
patent: 2003/0113811 (2003-06-01), Hale
patent: 2003/0175278 (2003-09-01), Monteiro
patent: 2004/0143860 (2004-07-01), St. George-Hyslop
patent: 2004/0154047 (2004-08-01), Scott
patent: 2004/0205836 (2004-10-01), Shen
patent: 2004/0265891 (2004-12-01), Arvizu
patent: 2004/0267004 (2004-12-01), Tohyama
patent: 2005/0101766 (2005-05-01), Blackstock
patent: 2005/0214837 (2005-09-01), St. George-Hyslop
patent: 2005/0288212 (2005-12-01), Hale
patent: 1967527 (2008-09-01), None
patent: 2007092861 (2007-08-01), None
Gandy, Sam; M. K. Doeven; and B. Poolman; “Alzheimer disease: presenilin springs a leak” Nature Medicine; Oct. 2006, vol. 12, No. 10, pp. 1121-1123.
Dewji, Nazneen N.; D. Mukhjopadhyay; and S. J. Singer; “An early specific cell-cell interaction occurs in the production of β-amyloid in cell cultures” PNAS, Jan. 31, 2006; vol. 103, No. 5, pp. 1540-1545.
Saura, Carlos A.; G. Chen; S. Malkani; S-Y Choi; R. H. Takahashi; D. Zhang; G. K. Gouras; A. Kirkwood; R. G. M. Morris; and J. Shen “Conditional Inactivation of Presenilin 1 Prevents Amyloid Accumulation and Temporarily Rescues Contextual and Spatial Working Memory Impairments in Amyloid Precursor Protein Transgenic Mice” The Journal of Neuroscience; Jul. 20, 2005; vol. 25, No. 29, pp. 6755-6764.
Beglopoulos, Vassilios; X. Sun; C. A. Saura, C. A. Lemere; R. D. Kim; and J. Shen; The Journal of Biological Chemistry Nov. 5, 2004; vol. 279, No. 45, pp. 46907-46914.
Cervantes, Sara; C. A. Saura; E. Pomares; R. Gonzales-Duarte; “Functional Implications of the Presenilin Dimerization” The Journal of Biological Chemistry, Aug. 27, 2004, vol. 279, No. 35. pp. 36519-36529.
Saura, Carlos A.; S-Y Choi; V. Beglopoulos; S. Maikani; D. Zhang; B. S. Shankaranarayana Roa; S. Chattarji; R. J. Kelleher, III; E.R. Kandel; K. Duff; A. Kirkwood; and J. Shen; “Loss of Presenilin Function Causes Impairments of Memory and Synaptic Plasticity Followed by Age-Dependent Neurodegeneration” Neuron, Apr. 8, 2004; vol. 42, pp. 23-36.
Dewji, Nazneen N.; D. Valdez; and S. J .Singer; “The presenilins turned inside out: Implications for their structures and functions” PNAS, Jan. 27, 2004, vol. 101, No. 4, pp. 1057-1062.
Pradier, Laurent; N. Carpentier; L. Delalonde; N. Clavel; M-D Bock; L. Buee; L. Mercken; B. Tocque; and C. Czech; “Mapping the APP/Presenilin (PS) Binding Domains: The Hydrophilic N-Terminus of PS2 Is Sufficient forInteraction with APP and Can Displace APP/PS1 Interaction” Neurobiology of Disease, 1999, vol. 6, pp. 43-55.
Smine, Abdelkrim; X. Xu; K. Nishiyama; T. Katada; P. Gambetti; S. P. Yadav; X.Wu; Y-C Shi; S. Yasuhara; V. Homberger; and T. Okamoto “Regulation of Brain G-protein Go, by Alzheimer's Disease Gene Presenilin-1” The Journal of Biological Chemistry; Jun. 26, 2998, vol. 273, No. 26, pp. 16281-16288.
Dewji, Nazneen N.; C. Do; and S. J. Singer “On the spurious endoproteolytic processing of the presenilin proteins in cultured cells and tissues” Proc. Natl. Acad. Sci. U.S.A., Dec. 1997, vol. 94, pp. 14031-14036.
Dewji, Nazneen N., and S. J. Singer, “The seven-transmembrane spanning topography of the Alzheimer disease-related presenilin proteins in the plasma membranes of cultured cells” Proc. Natl. Acad. Sci. U.S.A. Dec. 1997, vol. 94, pp. 14025-14030.
Dewji, Nazneen N., and S. J. Singer, “Cell surface expression of the Alzheimer disease-related presenilin proteins” Proc. Natl. Acad. Sci. U.S.A., Sep. 1997, vol. 94, pp. 9926-9931.
Dewji, Nazneen N.′ and S. J. Singer; “Genetic Clues to Alzheimer's Disease” Science, Jan. 12, 1996, vol. 271, pp. 159-160.
Dewji, Nazneen N., and S. J. Singer “Specific transcellular binding between membrane proteins crucial to Alzheimer disease” Proc. Natl. Acad. Sci., U.S.A. Oct. 1996 vol. 93, pp. 12575-12580.
Georgakopoulos, Anastasios, “Metalloproteinase/Presenilin1 processing of ephrinB regulates EphB-induced Src phosphorylation and sigaling”, The EMBO Journal, 2006, vol. 25, pp. 1242-1252.
Ulm, John D., Transmittal of International Search Report and Written Opinion, International Search Report, and Written Opinion, PCT/US07/07908, Aug. 25, 2008.
Dewji, Nazneen N., “Specific intercellular binding of the beta-amyloid precursor protein to the presenilins induces intercellular signaling: its significance for Alzheimer's disease.” Proc Natl Aced Sci USA, 1998, 95(25), pp. 15055-15060.
Dewji, Nazneen N., “The structure and functions of the presenilins.” Cell Mol Life Sci, 2005, 62(10), pp. 1109-1119. Review.
Dewji, Nazneen N., “Presenilin structure in mechanisms leading to Alzheimer's disease.” J Alzheimers Dis., 2006, 10 (2-3), pp. 277-290. Review.
Lunter, Pim, Supplementary European Search Report, Date of Completion of Search: Mar. 4, 2009, European Patent Application No. EP07754428.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Methods for screening agents that modulate presenilin... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Methods for screening agents that modulate presenilin..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods for screening agents that modulate presenilin... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-4178320

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.