Unstructured recombinant polymers and uses thereof

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Hormones – e.g. – prolactin – thymosin – growth factors – etc.

Reexamination Certificate

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C530S324000, C530S350000, C530S300000

Reexamination Certificate

active

07855279

ABSTRACT:
The present invention provides unstructured recombinant polymers (URPs) and proteins containing one or more of the URPs. The present invention also provides microproteins, toxins and other related proteinaceous entities, as well as genetic packages displaying these entities. The present invention also provides recombinant polypeptides including vectors encoding the subject proteinaceous entities, as well as host cells comprising the vectors. The subject compositions have a variety of utilities including a range of pharmaceutical applications.

REFERENCES:
patent: 3992518 (1976-11-01), Chien et al.
patent: 4088864 (1978-05-01), Theeuwes et al.
patent: 4200984 (1980-05-01), Fink
patent: 4284444 (1981-08-01), Bernstein et al.
patent: 4398908 (1983-08-01), Siposs
patent: 4435173 (1984-03-01), Siposs et al.
patent: 4542025 (1985-09-01), Tice et al.
patent: 4684479 (1987-08-01), D'arrigo
patent: 4861800 (1989-08-01), Buyske
patent: 4897268 (1990-01-01), Tice et al.
patent: 4933185 (1990-06-01), Wheatley et al.
patent: 4976696 (1990-12-01), Sanderson et al.
patent: 4988337 (1991-01-01), Ito
patent: 5017378 (1991-05-01), Turner et al.
patent: 5089474 (1992-02-01), Castro et al.
patent: 5176502 (1993-01-01), Sanderson et al.
patent: 5186938 (1993-02-01), Sablotsky et al.
patent: 5215680 (1993-06-01), D'arrigo
patent: 5223409 (1993-06-01), Ladner et al.
patent: 5270176 (1993-12-01), Dorschug et al.
patent: 5298022 (1994-03-01), Bernardi
patent: 5318540 (1994-06-01), Athayde et al.
patent: 5407609 (1995-04-01), Tice et al.
patent: 5492534 (1996-02-01), Athayde et al.
patent: 5554730 (1996-09-01), Woiszwillo et al.
patent: 5573776 (1996-11-01), Harrison et al.
patent: 5578709 (1996-11-01), Woiszwillo
patent: 5599907 (1997-02-01), Anderson et al.
patent: 5660848 (1997-08-01), Moo-Young
patent: 5756115 (1998-05-01), Moo-Young et al.
patent: 5874104 (1999-02-01), Adler-Moore et al.
patent: 5916588 (1999-06-01), Popescu et al.
patent: 5942252 (1999-08-01), Tice et al.
patent: 5965156 (1999-10-01), Proffitt et al.
patent: 5981719 (1999-11-01), Woiszwillo et al.
patent: 6024983 (2000-02-01), Tice et al.
patent: 6043094 (2000-03-01), Martin et al.
patent: 6056973 (2000-05-01), Allen et al.
patent: 6090925 (2000-07-01), Woiszwillo et al.
patent: 6110498 (2000-08-01), Rudnic et al.
patent: 6126966 (2000-10-01), Abra et al.
patent: 6183770 (2001-02-01), Muchin et al.
patent: 6254573 (2001-07-01), Haim et al.
patent: 6268053 (2001-07-01), Woiszwillo et al.
patent: 6284276 (2001-09-01), Rudnic et al.
patent: 6294170 (2001-09-01), Boone et al.
patent: 6294191 (2001-09-01), Meers et al.
patent: 6294201 (2001-09-01), Kettelhoit et al.
patent: 6303148 (2001-10-01), Hennink et al.
patent: 6309370 (2001-10-01), Haim et al.
patent: 6316024 (2001-11-01), Allen et al.
patent: 6329186 (2001-12-01), Nielsen et al.
patent: 6352716 (2002-03-01), Janoff et al.
patent: 6352721 (2002-03-01), Faour
patent: 6361796 (2002-03-01), Rudnic et al.
patent: 6395302 (2002-05-01), Hennink et al.
patent: 6406713 (2002-06-01), Janoff et al.
patent: 6458387 (2002-10-01), Scott et al.
patent: 6514532 (2003-02-01), Rudnic et al.
patent: 6517859 (2003-02-01), Tice et al.
patent: 6534090 (2003-03-01), Puthli et al.
patent: 6572585 (2003-06-01), Choi
patent: 6669961 (2003-12-01), Kim et al.
patent: 6713086 (2004-03-01), Qiu et al.
patent: 6715485 (2004-04-01), Djupesland
patent: 6733753 (2004-05-01), Boone et al.
patent: 6743211 (2004-06-01), Prausnitz et al.
patent: 6759057 (2004-07-01), Weiner et al.
patent: 6814979 (2004-11-01), Rudnic et al.
patent: 6838093 (2005-01-01), Flanner et al.
patent: 6890918 (2005-05-01), Burnside et al.
patent: 6905688 (2005-06-01), Rosen et al.
patent: 6945952 (2005-09-01), Kwon
patent: 7045318 (2006-05-01), Ballance
patent: 7413537 (2008-08-01), Ladner et al.
patent: 7442778 (2008-10-01), Gegg et al.
patent: 7514257 (2009-04-01), Lee et al.
patent: 7528242 (2009-05-01), Anderson et al.
patent: 2002/0042079 (2002-04-01), Simon et al.
patent: 2002/0150881 (2002-10-01), Ladner et al.
patent: 2003/0049689 (2003-03-01), Edwards et al.
patent: 2004/0106118 (2004-06-01), Kolmar et al.
patent: 2005/0042721 (2005-02-01), Fang et al.
patent: 2005/0048512 (2005-03-01), Kolkman et al.
patent: 2005/0118136 (2005-06-01), Leung et al.
patent: 2005/0260605 (2005-11-01), Punnonen et al.
patent: 2005/0287153 (2005-12-01), Dennis
patent: 2006/0026719 (2006-02-01), Kieliszewski et al.
patent: 2006/0084113 (2006-04-01), Ladner et al.
patent: 2006/0287220 (2006-12-01), Li et al.
patent: 2007/0048282 (2007-03-01), Rosen et al.
patent: 2007/0191272 (2007-08-01), Stemmer et al.
patent: 2007/0212703 (2007-09-01), Stemmer et al.
patent: 2008/0176288 (2008-07-01), Leung et al.
patent: 2008/0286808 (2008-11-01), Schellenberger et al.
patent: 2009/0092582 (2009-04-01), Bogin et al.
patent: 2009/0099031 (2009-04-01), Stemmer et al.
patent: WO 89/09051 (1989-10-01), None
patent: WO 97/33552 (1997-09-01), None
patent: WO 99/41383 (1999-08-01), None
patent: WO 9949901 (1999-10-01), None
patent: WO 2005/025499 (2005-03-01), None
patent: WO 2005/025499 (2005-03-01), None
patent: WO 2006/081249 (2006-08-01), None
patent: WO 2006/081249 (2006-08-01), None
patent: WO 2007/103455 (2007-09-01), None
patent: WO 2007/103455 (2007-11-01), None
patent: WO 2008/155134 (2008-12-01), None
Ackerman et al. Ion Channels—Basic Science and Clinical Disease. New Engl. J. Med.1997; 336:1575-1595.
Alvarez, et al. Improving Protein Pharmacokinetics by Genetic Fusion to Simple Amino Acid Sequences. J Biol Chem. 2004; 279: 3375-81.
Amin, et al. Construction of stabilized proteins by combinatorial consensus mutagenesis. Protein Eng Des Sel. 2004; 17: 787-93.
Antcheva, et al. Proteins of circularly permuted sequence present within the same organism: the major serine proteinase inhibitor from Capsicum annuum seeds. Protein Sci. 2001; 10: 2280-90.
Arap, et al. Steps toward mapping the human vasculature by phage display. Nat Med. 2002; 8: 121-7.
Assadi-Porter, et al. Sweetness determinant sites of brazzein, a small, heat-stable, sweet-tasting protein. Arch Biochem Biophys. 2000; 376:259-265.
Aster, et al. The Folding and Structural Integrity of the first LIN-12 Module of Human Notch1 are Calcium-Dependent. Biochemistry 1999; 38:4736-4742.
Barta, et al. Repeats with variations: accelerated evolution of the Pin2 family of proteinase inhibitors. Trends Genet. 2002; 18: 600-3.
Bateman, et al. Granulins: the structure and function of an emerging family of growth factors. J Endocrinol. 1998; 158: 145-151.
Bensch et al. hBD-1: a novel beta-defensin from human plasma. FEBS Lett 1995; 368:331-335.
Berger, et al. Phoenix mutagenesis: one-step reassembly of multiply cleaved plasmids with mixtures of mutant and wild-type fragments. Anal Biochem. 1993; 214: 571-9.
Beste, et al. Small antibody-like proteins with prescribed ligand specificities derived from the lipocalin fold. Proc Natl Acad Sci U S A. 1999; 96: 1898-1903.
Binz, et al. Engineering novel binding proteins from nonimmunoglobulin domains. Nature Biotechnology 2005; 23:1257.
Blanchette, et al. Principles of transmucosal delivery of therapeutic agents, Biomedicine & Pharmacotherapy. 2004; 58:142-152.
Bloch, Jr., et al. H NMR structure of an antifungal gamma-thionin protein Si alpha 1: Similarity to scorpion toxins. Proteins. 1998; 32: 334-49.
Bodenmuller, et al. The Neuropeptide Head Activator Loses Its Biological Acitivity by Dimerization. EMBO J. Aug. 1986; 5(8): 1825-1829.
Brooks, et al. Evolution of amino acid frequencies in proteins over deep time: inferred order of introduction of amino acids into the genetic code. Mol Biol Evol. 2002; 19, 1645-1655.
Calabrese, et al. Crystal Structure of Phenylalanine Ammonia Lyase: Multiple Helix Dipoles Implicated in Catalysis. Biochemistry. 2004; 43: 11403-16.
Calvete, et al. Snake venom disintegrins: Evolution of structure and function. Toxicon 2005; 45:1063-1074.
Calvete, et al. Snake venom disintegrins: Novel dimeric disintegrins and structural diversification by disulfphide bond engineering. Biochem J. 2003; 372:725-734.
Carr, et al. Solution structure of a t

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