Use of specific cyklolignans

Details Use of specific cyklolignans Use of specific cyklolignans

2008-01-29

2010-02-16

Andres, Janet L. (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C549S298000, C549S433000

Reexamination Certificate

active

07662851

ABSTRACT:
The invention refers to the use of specific cyclolignans, wherein the carbon atoms in positions 9 and 9′ have cis configuration, for inhibition of the insulin-like growth factor-1 receptor. Said compounds can be used for treatment of IGF-1R dependent diseases, such as cancer, psoriasis, atherosclerosis and acromegaly. A preferred compound is picropodophyllin.

REFERENCES:
patent: 1075316 (1993-08-01), None
patent: 0188248 (1986-07-01), None
patent: 61-267541 (1986-11-01), None
patent: 62-501360 (1987-06-01), None
patent: 09-194368 (1997-07-01), None
patent: WO8604062 (1986-07-01), None
patent: WO99/28347 (1999-10-01), None
patent: WO 00/00238 (2000-01-01), None
CN1075316, Dolatrai et al, (1993) abstract, best availble.
Gordalizqa et al, Arch. Pharm. vol. 327 pp. 175-179 (1994).
Dantzig et al, J.Med. Chem. vol. 44 pp. 180-185 (2001).
Iwasaki et al, J. Med. Chem. vol. 39 pp. 2696-2704 (1996).
S. Shashikanth, et al., Indian Journal of Heterocyclic Chemistry, vol. 5, No. 3, Jan.-Mar. 1996, pp. 185-188.
Japanese Office Action dated Mar. 4, 2009 in corresponding application JP2003-506277 (English Translation).
Japanese Office Action dated Mar. 4, 2009 in corresponding application JP2003-506278 (English Translation).

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